Category: Care

Cancer is increasingly becoming a highly manageable disease

In the Sunday edition of To Vima newspaper and Vita magazine (25 January 2026), the views of Ms Evangeli Bista, co-founder of Kapa3, were featured, shedding light on the landscape of modern oncology and the challenges emerging within the current Greek healthcare reality.

Ms Bista addressed the Greek context and highlighted the importance of digital technology as a cornerstone of modern health policy, particularly in the field of cancer care, where treatment pathways are complex, long-term, and deeply person-centred. As she noted, Greece has already made measurable progress: electronic and paperless prescribing, oncology registries, the National Electronic Health Record, and applications such as MyHealthApp are creating the conditions for more coordinated and transparent care. When healthcare professionals, as well as patients themselves, are equipped with appropriate digital skills, patient autonomy is strengthened, treatment outcomes improve, and inequalities—especially those affecting vulnerable population groups—are reduced.

The article is co-authored by distinguished scientists and collaborators: Maria Gazouli, Professor of Biology, Genetics and Nanomedicine at the Medical School of the National and Kapodistrian University of Athens and national representative on the Committee for Advanced Therapies of the European Medicines Agency; Manolis Saloustros, Associate Professor of Oncology at the University of Thessaly and President of the Hellenic Society of Medical Oncology (HESMO); and Christos Frantzidis, Assistant Professor of Informatics and Machine Learning at the University of Lincoln in the United Kingdom.

The contributing experts underline that modern oncology increasingly approaches cancer as a largely manageable chronic disease, through targeted and personalised therapies. The use of innovative technologies—such as next-generation sequencing, mRNA vaccines, PARP inhibitors and cellular therapies—has significantly expanded therapeutic options. At the same time, prognosis is becoming more dynamic and individualised through the use of multi-omics profiling, machine learning algorithms and liquid biopsy techniques. Particular emphasis is placed on the early integration of palliative care and psychosocial support, which play a crucial role in improving patients’ quality of life. Finally, the importance of structured and coordinated healthcare services is highlighted, with the medical oncologist acting as a key coordinator of person-centred care.

Beyond documenting technological advances, the article opens a broader discussion on the digital transition in oncology care, addressing issues of access, meaningful use of data and the need for coordination across different scientific disciplines. Digital health is presented not as an end in itself, but as a tool that requires collaboration, institutional maturity and a shared vision in order to deliver real value to patients.

The overarching message is clear: every step, whether small or large, matters. Progress in oncology is not the result of isolated actions, but of collective effort. Through collaboration among scientists, healthcare professionals, organisations and patients, the conditions for meaningful and sustainable change can be created—always with the human being and their real needs at the centre.

Text / Adaptation: Ifiyenia Anastasiou for Kapa3

The Visit of Love: a shared act of care and hope

In December 2025, Kapa3 took part once again the Visit of Love, an initiative by WinCancer that aims to bring warmth, presence, and emotional support to those who will spend the holiday season in oncology hospitals.

Once again, the response was deeply moving.

Cards and messages arrived from all over — through the post, by courier, in parcels both large and small, and sometimes delivered by hand. Each one carried a simple but powerful message: you are not alone.

Among them were cards written by preschool children, some with their very first letters, others expressed through drawings and colours. Messages full of innocence, light, and hope — “get well so we can eat Christmas cookies together.”

There were also messages from adults who had faced cancer in the past and now shared their words of encouragement together with their children, closing a circle of empathy and solidarity.

This action is addressed to everyone who will spend the holidays in oncology hospitals — patients, companions, and healthcare professionals alike — acknowledging the emotional weight of these days and the importance of human connection.

The process was intense, emotional, and, at times, chaotic.

Glitter and golden dust filled desks, clothes, and hair. While those traces will eventually disappear, the love, smiles, and hope that passed through our hands will remain.

For Kapa3, supporting initiatives like the Visit of Love is an essential part of our mission: to strengthen collaboration, promote solidarity, and contribute to actions that place human connection at the centre of care.

We warmly thank WinCancer for the trust and collaboration, as well as everyone who participated and offered a piece of their heart. Together, we can continue creating moments that matter.

Until next year, we hold on to the love, the hope, and the reminder that small gestures can make a big difference.

Text: Ifiyenia Anastasiou for Kapa3

International Universal Health Coverage Day – December 12

International Universal Health Coverage (UHC) Day is observed every year on December 12 to remind us that access to quality, affordable healthcare is a fundamental human right and a cornerstone of just and sustainable societies. The United Nations established this day to strengthen global commitment so that all people, everywhere, can access the health services they need without financial hardship. (WHO)

Statistics

Universal health coverage is not just a goal. It is a central element of the United Nations  Sustainable Development Goals for 2030. Despite progress in recent decades, the reality remains challenging. Approximately 4.6 billion people worldwide still lack access to essential health services. At the same time, 2.1 billion face financial hardship in accessing care. Finally 1.6 billion pushed into poverty due to health expenditures.

These statistics demonstrate that universal coverage remains far from fully achieved, with significant inequalities between countries and within societies: poorer populations, rural residents, people with lower education, and other vulnerable groups face much greater barriers to healthcare. (WHO – World Bank Report)

Situation in Greece

In Greece, although universal coverage exists in principle through the National Health System, access to care is not always equitable or complete. Only a small percentage of citizens report high satisfaction with service availability, while around 12.1% of people have unmet healthcare needs, a rate significantly higher than the OECD average. (OECD)

Out-of-pocket healthcare expenses particularly affect lower-income households. Nearly nearly 10% of households facing catastrophic health spending, forcing families to sacrifice essentials such as food or housing. (WHO – Health Care Greece)

These inequalities are not just numbers—they have real consequences for quality of life. For cancer patients, universal coverage means timely diagnosis, access to treatments, continuous monitoring, psychosocial support, and palliative care. Lack of comprehensive, accessible care can worsen disease outcomes and increase psychological and financial burden for patients and their families.

At Kapa3, we strive to ensure that no cancer patient or their loved ones feel alone. Through educational initiatives, experiential programs, psychosocial support, and guidance materials, we advocate for healthcare access that respects human dignity, life, and real needs.

Universal Health Coverage Day is not just a date—it is a call to action for broader access, reduced inequalities, and genuine support for all. Together, we can make meaningful change.

Text/adaptation: Ifiyenia Anastasiou for Kapa3

This Year’s Good-Luck Charm (2026): A Symbol of Self-Care

The Good Luck Charm of the Year (2026) for Kapa3: The Crown

A Symbol of Self-Care

This year’s good luck charm is dedicated to self-care — a small, daily reminder of the deep importance of tending to ourselves with gentleness, respect, and consistency.
In a time when everyday life becomes increasingly demanding, this charm reminds us that self-care is not a luxury, but a necessity.

It symbolizes all those small acts that keep us standing: the pause, the breath, the moment of rest; the warm embrace we offer ourselves. The choice to listen to our bodies, to acknowledge our limits, and to prioritize our health, joy, and inner balance.

And it is precisely this “pause” that led us to our good-luck charm for 2026: the Crown — a symbol that carries far more than what meets the eye.

In music, the crown (fermata) is the pause held by the performer —
the moment of emphasis before the melody continues.
So it is with every struggle: it requires breaths, pauses, small breaks — not to stop, but to continue.

A crown is also a circle. And a circle means you are not alone; around you are people, care, support — a circle that holds you.

If there were a title of honor for those who fight cancer, it would be a crown. Not as a symbol of power, but as a recognition of dignity.

Cancer can sometimes feel like a thorny wreath — heavy, painful, relentless.
And yet, depending on how we choose to face it, it can transform into a wreath of victory: the victory of persistence, endurance, return — and above all, the victory of effort.

Because behind every crown lies a story: of a parent, a friend, a child, a partner, someone who is fighting or supporting someone who fights.

That is why the crown is not just a piece of jewelry — it is a message of strength:

It is not what happens to us that defines us —
but how we choose to face it.

It reminds us that when we care for ourselves, we can truly care for others. That strength, well-being, and kindness begin within us.

May this year’s charm be a small talisman accompanying us each day, inspiring us to make space for what nourishes us, to embrace our vulnerability, and to celebrate our worth.

For a year filled with more care, more peace, and more love — beginning with ourselves.

Let’s fill our days with small acts that make a difference.
Let’s uplift one another.
Let’s turn self-care into a habit.

And for all of us at Kapa3, the invitation is simple: To weave self-care into our everyday lives.

Join the #kapa3gouri Self-Care Challenge

Inspired by this year’s charm — dedicated to self-care — we invite you to join the #kapa3gouri Self-Care Challenge, a collective action that brings us together through moments of care, calm, and mindfulness.

How the challenge works:

  1. Take one small self-care action during your day.
    It can be something simple: a walk, a breathing break, a warm cup of tea, a few minutes away from screens, journaling your thoughts, a hug you needed.

  2. Capture a photo or write a few words that reflect that moment.

  3. Share it on Instagram or Facebook using the hashtag #kapa3gouri.

  4. Tag two friends to keep the chain of self-care going.

Our goal is not the “perfect” image — but the daily reminder that we deserve time, space, and care. Each post becomes a small mosaic of tenderness toward ourselves.
A collective message that wellbeing begins within.

For 2026, choose the Crown — as a symbol of hope, strength, and dignity.
Wear it. Offer it. Share its power.

Thank you for being part of this journey.


The Kapa3 Team

 

 

When Art Meets Science: How CREATE Platform May Strengthen Emotional Regulation in Cancer Care

At Kapa3, we recognize that cancer affects far more than the body, challenging the emotions, sense of self, relationships, and quality of life of those suffering. Despite the high prevalence of co-occuring mental health issues such as anxiety and depression, access to mental health services remains limited. This gap between patient needs and healthcare provisions is precisely what motivated us to help develop CREATE, an innovative digital platform designed to support emotional resilience through a powerful combination of art, technology, and emotional engagement (Ladas et al., 2025).

The CREATE (Creative and Resilience through Arts, Technology, and Emotions) platform uses computerised cognitive training (CCT) designed to enhance emotional regulation by integrating working memory training, engagement with famous artwork, and creative emotional expression. Unlike other platforms, it only targets one cognitive function: working memory. Evidence suggests that focusing on a single cognitive function is more effective than targeting multiple ones. Working memory in particular has been found to influence emotional regulation, a skillset with established benefits for anxiety and depression.

CREATE therefore introduces a unified framework that addresses cognitive function, emotional expression, and biological influences such as sleep quality and dopamine activity. Such digital health solutions are increasingly recognized as promising alternatives to standard psychotherapy, offering greater accessibility and affordability while still capable of reducing symptoms of depression and anxiety.

Findings from the pilot study on CREATE were very promising; the participants found the platform easy to use and enjoyable, and showed increased emotional and creative engagement. Although this early research focused on feasibility and validity rather than therapeutic effectiveness, initial findings indicate improvements in emotional regulation. Importantly, the study demonstrated positive relationships between working memory, emotional regulation, and expression of emotion, while also suggesting that sleep and dopamine may mediate these effects.

These insights highlight the importance of lifestyle and biological data in developing personalized digital mental health tools. It is well established in neuroscience that working memory plays a central role in emotional regulation. A stronger working memory allows individuals to better cope with distressing thoughts, shift their attention, and respond more calmly to challenges. For people living with cancer, supporting these cognitive and emotional capacities makes daily life more manageable. Improved thinking skills can facilitate treatment adherence, informed decision-making, and a more effective management of the emotional turbulence that often accompanies illness.

The study relied on a convenience sample made up mostly of cancer-related healthcare professionals, and only one cancer survivor participated. To address this limitation, the next phase of research will focus entirely on cancer patients and survivors. Their unique challenges, including cancer-related fatigue and treatment-related cognitive changes, will be central to refining the platform and ensuring that CREATE is tailored to the needs of those it aims to benefit the most. This creates not only a more impactful intervention but also empowers patients to have a voice in shaping the future of supportive cancer care.

As we look ahead, CREATE offers a hopeful vision for digital mental-health support. It is scalable, affordable, and adaptable, making it especially valuable for people who lack access to mental health care. Intervening early and supporting emotional well-being throughout treatment and survivorship may reduce the long-term strain on healthcare services associated with mental health conditions.  As cancer treatment continues to evolve, we must make sure that psychological care develops along with it. And CREATE does just that.

Read the full study

References

Ladas, A. I., Katsoridou, C., Gravalas, T., Klados, M. A., Stravoravdi, A. S., Tsompanidou, N., Fragkedaki, A., Bista, E., Chorafa, T., Petrovic, K., Vlotinou, P., Tsiakiri, A., Papazisis, G., & Frantzidis, C. A. (2025). Creativity and REsilience Through Arts, Technology and Emotions: A Pilot Study on the Feasibility and Validity of the CREATE Platform. Brain Sciences, 15(11), 1171.

‌Article by Despina Chrysostomidou, Psychologist, for Kapa3 Research Insights

Depression and Cancer Mortality: A Critical Link Across Major Cancer Types

Depression is a common but often underrecognized condition among cancer patients, affecting up to 20–30% of individuals diagnosed with the disease. Beyond its impact on quality of life, mounting evidence suggests that depression can significantly influence cancer outcomes, including survival. A recent meta-analysis of 65 cohort studies spanning colorectal, breast, lung, prostate, and mixed cancers provides compelling evidence that depression diagnosed after a cancer diagnosis is associated with a substantially increased risk of mortality.

The analysis revealed that patients with depression faced an 83% higher risk of dying from colorectal cancer, a 59% higher risk in lung cancer, a 74% higher risk in prostate cancer, and a 23% higher risk in breast cancer compared to non-depressed patients. Across mixed cancer types, depression increased the risk of cancer mortality by 38%. These findings underscore that the psychological burden of cancer is not merely an emotional challenge but a critical factor affecting survival outcomes.

Mechanisms Linking Depression and Cancer Outcomes

Depression may influence cancer progression through multiple biological and behavioral pathways. Biologically, depression is associated with chronic systemic inflammation, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, immune suppression, autonomic dysfunction, oxidative stress, and impaired DNA repair. Elevated pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), can contribute to tumor growth and metastasis. In older patients, depression may exacerbate age-related immune dysfunction, creating an environment more permissive to cancer progression.

Behaviorally, depression affects health-related actions and treatment adherence. Depressed patients are more likely to delay seeking medical care, adhere poorly to chemotherapy, radiotherapy, and hormonal therapies, and engage in unhealthy habits such as smoking, poor nutrition, and physical inactivity. Social isolation and reduced support systems further increase vulnerability, compounding the negative impact on survival.

Clinical Implications and Interventions

The strong association between depression and cancer mortality highlights the urgent need to integrate mental health care into routine oncology practice. Psychological interventions, such as cognitive-behavioral therapy (CBT), supportive-expressive therapy, and mindfulness-based approaches, have shown promise in reducing distress and improving adherence to cancer treatment. Pharmacological management, including selective serotonin reuptake inhibitors (SSRIs), may also support mental health and potentially influence cancer outcomes, though more research is needed to understand their role fully. Early identification and treatment of depressive symptoms should be considered a priority for oncologists, mental health professionals, and healthcare policymakers alike.

Limitations and Future Directions

While this meta-analysis provides robust evidence, several limitations should be noted. The observational nature of the studies prevents establishing causality, and differences in study design, depression assessment methods, and patient populations contribute to heterogeneity. Future research should explore longitudinal and randomized studies to clarify causal pathways and identify the most effective interventions to reduce depression-related mortality. Investigating the interactions between depression, inflammation, and cancer biology may also reveal targets for novel supportive therapies.

Depression is not just a psychological burden for cancer patients—it is a significant predictor of mortality across multiple cancer types. These findings call for systematic depression screening and tailored interventions as integral components of oncology care.

Organizations like Kapa3 play a vital role in supporting the mental health of cancer patients, offering resources and guidance that can improve both quality of life and treatment outcomes. Integrating psychological support into cancer care ensures that mental well-being is recognized as an essential part of the healing process.
In line with this mission, Kapa3 participates in MELODIC, a new European initiative dedicated to supporting the mental health of young adults (18–30 years old) living with or beyond cancer.

Read the original article here

Read more on MELODIC project here

Explore more about mental health through a selection of articles on our website: article1 article2,article3, article4, article5, article6 

Text/adaptation: Ifiyenia Anastasiou for Kapa3

 

EGFR: An “Old Target” Gaining New Life in Cancer Research

When science moves forward step by step

Progress in oncology does not always come with dramatic announcements. Often, it is found in studies that show small but meaningful steps. One such case is a recent review in JAMA Oncology exploring new targeted therapies for head and neck cancer — a type of cancer often linked to smoking, alcohol consumption, or HPV infection. At Kapa3, we closely follow these developments to keep patients and their families responsibly informed,

Researchers focused on a protein called EGFR (Epidermal Growth Factor Receptor). Approximately 90% of patients with this type of cancer show overexpression of the protein, making it an attractive target for therapy. In the past, drugs such as cetuximab attempted to “block” EGFR activity, but results were limited. Patients experienced modest improvements without a significant increase in survival.

The new generation of research goes a step further. Combination therapies are being explored, such as targeting EGFR alongside immunotherapy (e.g., pembrolizumab), which strengthens the body’s defense against cancer cells. In early studies, this combination showed response rates around 45% and a median survival of approximately 18 months in patients for whom previous treatments had failed — results that, while not dramatic, are considered encouraging for this disease.

Scientists now understand that the success of targeted therapy depends on multiple factors. In many patients, cancer cells eventually develop resistance, “learning” to bypass the drug’s effect. In addition, cancers linked to HPV appear to behave differently from those that are not, opening new avenues for more personalized approaches.

Research is also focusing on identifying biomarkers — molecular indicators that can show which patients are most likely to benefit from a particular therapy. If these tools prove reliable, they could lead to more targeted, effective, and safer treatments in the future.

At the same time, newer forms of drugs are being tested, such as bispecific antibodies and antibody–drug conjugates, which aim to target cancer cells with greater precision. All of these efforts are still in early clinical trial stages, aiming to improve efficacy and reduce side effects.

The key message of this research is not that a “new drug that beats cancer” has been found, but that science continues to search, test, and learn. Every small step, every percentage of improvement, every new idea paves the way for future progress.

For people living with cancer — and their families — hope lies not only in major breakthroughs and new treatments but also in the certainty that thousands of researchers around the world are tirelessly working to make each next step a little closer to life. Because in science, as in life, progress is often measured not in leaps but in steady, human steps. At Kapa3, we are committed to sharing this news in a clear and useful way for everyone.

Read the review here

Sources:

Hwang W. et al. “Emerging EGFR-Targeted Therapy in Head and Neck Cancer: A Review.” JAMA Oncology (2025).
World Health Organization – Cancer Research Updates

Text/adaptation: Ifiyenia for Kapa3

Continuing the Journey: Holistic Body and Mind Care with Kapa3 and the University of the Peloponnese

After the first round of meetings held in April (see the related article here), focusing on Nutritional Guidance and Experiential Psychological Support, Kapa3 and the University of the Peloponnese continue their collaboration with a new series of experiential workshops dedicated to the holistic care of body and mind.

The meetings are open to people living with cancer, caregivers, and healthcare professionals — to anyone seeking a space for genuine communication, understanding, and empowerment.

In this new cycle, mental health and nutrition are approached as two sides of the same care.

In the mental health sessions, participants learn to recognize and manage challenging emotions such as anxiety or fear, strengthen their resilience, and cultivate a deeper connection with themselves and others.

At the same time, the nutrition sessions explore how balanced and mindful eating can support the body, enhance energy and mood, and become an act of self-care and self-respect. Food is not only a necessity but also a way to show love — to the body, the soul, and to life itself.

The meetings are held online and are based on dialogue, experiential learning, and the sharing of personal experiences. Everyone participates at their own pace, in a warm environment of acceptance and trust.

To express your interest: Registration Form for the Support Group for People with Cancer

Text/adaptation: Ifiyenia for Kapa3

Understanding Breast Cancer Risk Factors: What You Can and Can’t Change

October is Breast Cancer Awareness Month — a time to raise awareness, share knowledge, and remind ourselves of the importance of early detection and prevention. One of the most common questions people ask is: “What can I do to lower my risk of breast cancer?”

The truth is that while doctors don’t know exactly what causes breast cancer, research has identified certain factors that increase the likelihood of developing the disease. Some of these are beyond our control, while others are linked to lifestyle choices and can be modified. By learning the difference, we empower ourselves to take the best possible care of our health.

Unchangeable Risk Factors

Some risk factors cannot be avoided. These include:

  • Sex: Being female or assigned female at birth is the biggest risk factor.
  • Age: Risk increases with age; two out of three invasive breast cancers occur in women 55 or older.
  • Family History and Genetics: A family history of breast cancer or inherited genetic mutations (such as BRCA1/2) increases risk.
  • Personal History: Women previously diagnosed with breast cancer are more likely to develop it again.
  • Past Radiation: Radiation to the chest or face before age 30 raises risk.
  • Certain Breast Conditions: Some non-cancerous breast changes are linked to higher risk.

Lifestyle-Related Risk Factors

Our daily habits and choices also play a significant role:

  • Weight: Being overweight, especially after menopause, increases risk.
  • Physical Activity: Lack of regular exercise is linked to higher risk.
  • Smoking and Alcohol: Both are associated with increased breast cancer risk.
  • Hormonal Factors: Use of hormone replacement therapy (HRT) or hormonal contraception may raise risk in some women.
  • Reproductive History: Age at first childbirth, number of pregnancies, and breastfeeding history all influence risk.
  • Menstrual History: Early onset of menstruation is associated with slightly higher risk.

Emerging Risk Factors

Research is ongoing, but some additional factors are being studied, such as:

  • Low vitamin D levels.
  • Night-shift work and exposure to bright light at night.
  • Exposure to chemicals (in food, plastics, cosmetics, sunscreens, pesticides, pollution).
  • Frequent consumption of grilled or smoked meats.
  • High levels of air pollution.

Myths and Misconceptions

It’s equally important to clear up what does not increase risk. Research shows no evidence that abortion, antiperspirants, bras, or dairy products cause breast cancer.

We may not be able to control every risk factor, but every small step toward a healthier lifestyle truly makes a difference. Exercise, balanced nutrition, limiting alcohol, and avoiding smoking are not just prevention measures — they’re acts of daily self-care.
At Kapa3, we believe that awareness and support save lives. No one is ever alone on this journey. We promise to continue to speak openly, share knowledge, and stand beside every woman. Because awareness is not about fear; it’s about strength, hope, and small steps toward a healthier tomorrow.

Read More here: https://www.breastcancer.org/risk/risk-factors

Text/Adaptation: Ifiyenia for Kapa3

World Mental Health Day

Every year on 10 October, the world raises its voice for mental health. The World Health Organization reminds us that there is no health without mental health — a truth that is especially important for people living with cancer.

A cancer diagnosis, the treatments, and the uncertainty about the future can create a heavy emotional burden. Many patients experience anxiety, sadness, or feelings of isolation. Studies show that around 30% of people with cancer face psychological challenges such as depression or post-traumatic stress — conditions that affect not only mood but also treatment outcomes and overall well-being.

Psychological distress is not merely a natural reaction to illness; it can influence the immune system, increase chronic inflammation, and reduce the body’s resilience. Behaviourally, it may lead to delays in seeking care, poor adherence to treatment, and social withdrawal. That’s why psychological support is an essential component of cancer care.

A growing body of research shows that interventions like cognitive-behavioral therapy (CBT) and mindfulness-based practices significantly reduce anxiety, depression, fatigue, and stress, while enhancing resilience, post-traumatic growth, and quality of life. Mindfulness-based stress reduction (MBSR), art-based mindfulness, and guided meditation are all proven to help patients regain emotional balance and strength.

At Kapa3 – Cancer Guidance Center, we believe care extends beyond medical treatments. Human connection, understanding, and the sense that “you are not alone” can make all the difference. By providing information, support, and a compassionate presence, we aim to lighten the emotional load for both patients and their families.

World Mental Health Day reminds us that caring for the patient is holistic. Cancer is not only a physical battle; it is an emotional journey — and no journey should be faced alone.

References / Learn more: