Adolescents and Young Adults with Cancer (AYAs): When a Diagnosis Comes During the Most Formative Years of Life

The unique psychosocial challenges, the invisible signs of distress, and Kapa3’s holistic response through the European MELODIC project.

A cancer diagnosis during adolescence or young adulthood often comes at a time when life is unfolding through some of its most creative and defining stages. Education, employment, romantic relationships, independence, starting a family, and planning for the future are all taking shape. A cancer diagnosis can abruptly interrupt this journey, creating a reality that is often difficult to comprehend, even for the young people experiencing it.

Adolescents and young adults with cancer, internationally referred to as AYAs (Adolescents and Young Adults), represent a distinct population within oncology. Their needs extend far beyond the treatment of the disease itself. They encompass identity, autonomy, relationships, sexuality, fertility, education, employment, financial security, and, above all, how they perceive their future and themselves.

When Life Is Put on Hold

For a young person, experiencing cancer can create the feeling that their personal life has come to a standstill while their peers continue moving forward. Friends pursue their studies, build careers, travel, develop relationships, and start families, while they may be coping with hospitalisations, treatments, fatigue, and restrictions on everyday activities.

This disruption can significantly affect their psychological well-being. Social isolation, changes in body image, concerns about sexuality and intimate relationships, and fears about potential effects on fertility are issues that may not always be easy to discuss with family members or even with the healthcare team.

At the same time, interruptions to education or employment can create financial uncertainty and undermine a young person’s sense of independence.

The impact of cancer, therefore, is not limited to the physical body. It extends to how young people perceive themselves, their identity, and their place within society.

Psychological Distress Is Not Always Visible: Recognising the Warning Signs

One of the most important challenges in caring for AYA patients is that psychological distress is not always immediately recognisable.

Distress may emerge at different stages of treatment, including after treatment has ended, and can manifest in various ways.

It may be expressed through anger towards the healthcare team, mistrust of treatment or medical recommendations, repeated questioning or, conversely, complete avoidance of questions.

It may also appear as delayed or missed appointments, difficulty adhering to treatment, excessive reliance on information found online, or reluctance to seek support from family members and social networks.

At other times, the signs are even more subtle: withdrawal from friends, reduced participation in activities, feelings of loneliness or hopelessness, or the belief that “no one can understand what I am going through.”

These behaviours should not automatically be interpreted as non-cooperation or lack of motivation. They may reflect emotional distress, uncertainty, fear, or unmet psychosocial needs that require further exploration.

This is why communication is a fundamental component of care.

An open-ended question, a safe and supportive environment, and, above all, a genuine willingness to listen without minimising a young person’s feelings can provide the starting point for identifying needs at an early stage.

Completing Treatment Does Not Always Mean the End of the Struggle

Another important message concerns the period following the completion of cancer treatment.

The end of oncology treatment is often accompanied by relief and optimism. At the same time, however, it can create a new sense of uncertainty or emptiness.

Frequent contact with the hospital and healthcare professionals gradually decreases, while young people are expected to return to everyday life and redefine their identity and future after cancer.

Fear of recurrence, changes in relationships, returning to work or education, and the need to reconsider personal goals may create new psychological challenges.

Psychological recovery, therefore, does not necessarily follow the same timeline as physical recovery.

Importantly, resilience and psychological distress are not mutually exclusive.

A young person may continue moving forward, pursuing their goals and rebuilding their life, while simultaneously experiencing fear, uncertainty, or emotional difficulties.

Recognising this complexity is essential to avoid unrealistic expectations that young people should immediately return to their previous lives or feel consistently positive once treatment has ended.

From Recognition to Meaningful Support and Effective Interventions

Addressing these needs requires an approach that sees the AYA patient as a whole person, not simply as someone undergoing cancer treatment.

Active listening, encouraging emotional expression, strengthening autonomy, and facilitating access to appropriate psychosocial support services are essential elements of comprehensive care.

Support may include psychological and social care, peer-support groups, counselling, and practical assistance related to employment, financial concerns, or social rights.

Individualisation is particularly important.

Not all young people require the same type of support, nor do they experience cancer in the same way.

Age, family circumstances, social environment, personal values, and life goals all contribute to shaping different needs and expectations.

Evidence-Informed Psychotherapeutic Approaches

Several psychotherapeutic approaches may help address the psychological and emotional challenges experienced by adolescents and young adults affected by cancer.

Cognitive Behavioural Therapy (CBT) can help young people identify and reframe unhelpful patterns of thinking, develop more adaptive coping strategies, and regain a sense of control during periods of significant uncertainty.

Acceptance and Commitment Therapy (ACT) emphasises psychological flexibility, the recognition and acceptance of difficult emotions, and engagement with personal values. This approach may be particularly relevant when illness has disrupted a young person’s priorities, identity, or future plans.

In parallel, meaning-centred approaches can support AYA patients in addressing existential concerns, changes in identity, and experiences of loss.

These interventions may help individuals integrate the experience of cancer into their evolving understanding of themselves and their lives, while rediscovering meaning, purpose, and personal direction.

The Importance of Peer Support

Peer support represents another valuable dimension of psychosocial care.

Connecting with people who have experienced similar challenges can reduce feelings of social isolation, strengthen the sense that “I am not alone,” and create opportunities for mutual understanding.

Peer relationships may also provide a supportive environment in which young people feel more comfortable discussing concerns that can be difficult to communicate with family members or healthcare professionals.

These forms of support should be adapted to individual circumstances and preferences.

Psychotherapeutic and psychosocial interventions need to be delivered flexibly, taking into account each person’s developmental stage, cultural and social context, values, and changing needs.

The therapeutic relationship, trust, respect for autonomy, and the active involvement of young people in decisions affecting their care are fundamental components of a genuinely person-centred approach.

MELODIC and the Need for More Human-Centred Cancer Care

This need lies at the heart of the European project MELODIC – Mental Health Support for Young Adults with Cancer, in which Kapa3 – Cancer Guidance Centre participates as a project partner.

MELODIC focuses on the mental health and well-being of young adults affected by cancer, aiming to strengthen the knowledge, skills, and support available to them, their loved ones, and the professionals involved in their care.

The project specifically addresses the needs of young adults aged 18–35 and seeks to promote a more integrated, supportive, and human-centred approach to oncology care.

Within the framework of MELODIC, Kapa3 has actively contributed to the co-development of educational materials, the development of the educational framework, and the pilot educational intervention in Greece.

Through this participation, Kapa3 supports the recognition of psychosocial needs and the development of knowledge and competencies among healthcare professionals working with young people affected by cancer.

This approach is directly aligned with the philosophy of holistic cancer care: mental health is not a separate or secondary concern but an integral part of the overall experience of living with cancer.

MELODIC also highlights the importance of interdisciplinary collaboration and the early identification of psychosocial needs.

By strengthening awareness and professional competencies, healthcare professionals can become better equipped to recognise signs of distress and refer young people to appropriate support services in a timely and coordinated manner.

From Identifying Needs to Developing Supportive Interventions

The MELODIC project promotes an approach that moves beyond identifying psychological challenges towards developing practical, person-centred interventions that respond to the everyday realities of young adults living with cancer.

Its broader framework recognises the value of psychosocial support, social connection, physical activity, and engagement with nature as complementary dimensions of well-being.

For Kapa3, participation in MELODIC reflects a wider commitment to connecting scientific knowledge with practical support and the lived experiences of people affected by cancer.

By contributing to European collaboration, educational activities, and the development of supportive interventions, Kapa3 seeks to help strengthen a model of cancer care that is more responsive to the individual, social, and emotional needs of patients.

This commitment also reflects the organisation’s broader work in patient navigation, health literacy, access to rights, and psychosocial support.

Because meaningful cancer care must extend beyond medical treatment and recognise the person behind the diagnosis.

Why Listening to Young People Matters

Meaningful care begins with a simple but fundamental principle: listening.

Listening to the young person who is afraid, even when they cannot express that fear directly.

Listening to the person who feels angry, withdraws from others, or struggles to follow their treatment plan.

Listening to those who appear to be coping well but may be experiencing greater emotional difficulties than they reveal.

Listening without judgement, without minimising emotions, and without assuming that the needs of all young people affected by cancer are the same.

Behind every diagnosis is a person who continues to have relationships, plans, dreams, ambitions, and a need for independence.

Through its participation in MELODIC, alongside its broader activities supporting people living with cancer, Kapa3contributes to promoting a model of care that does not end with the treatment of the disease.

A model that recognises psychological and social needs, strengthens patient empowerment, and builds bridges towards appropriate support.

A model that understands that recovery is not only about physical health but also about rebuilding confidence, identity, relationships, and the ability to imagine a future.

Because cancer care is not only about helping people recover from illness. It is also about supporting them, with dignity and understanding, as they rebuild the lives they want to live.

Learn More About MELODIC

The European project MELODIC – Mental Health Support for Young Adults with Cancer aims to promote mental health and well-being among young adults affected by cancer through interdisciplinary collaboration, education, and person-centred supportive interventions.

Kapa3 participates in the project, contributing to its activities in Greece and to the broader European effort to strengthen psychosocial cancer care.

For more information about MELODIC, its objectives, activities, and Kapa3’s participation, visit the dedicated section of our website:

https://www.kapa3.gr/melodic/

If you are a young adult aged 18–35 with lived experience of cancer and would like to learn more about the project or possible opportunities for involvement, please contact the Kapa3 team.

Kapa3 – Cancer Guidance Centre

Website: https://www.kapa3.gr
Email: info@kapa3.gr
Telephone: +30 210 5221424

Source

Ciampa, D., Mathew, L., Fulginiti, K., & Fortune-Kottis, S. (2026, August 11). Addressing unique psychosocial challenges in adolescent and young adult (AYA) patients with cancer. Oncology Central.

https://www.oncology-central.com/addressing-unique-psychosocial-challenges-in-adolescent-and-young-adult-aya-patients-with-cancer/

Further information:
European MELODIC Project – Kapa3
https://www.kapa3.gr/melodic/

Article edited by:
Elena Panopoulou
Sociologist, Kapa3 Tripoli Team

Email: elenak3team@gmail.com
LinkedIn: https://www.linkedin.com/in/elena-panopoulou-5061aa426

Modern Oncology: When Survival Is Not Enough

New therapies, “hidden” effects and the need to assess not only how long patients live, but how they live

Modern Oncology: When Survival Is Not Enough

New therapies, “hidden” effects and the need to assess not only how long patients live, but how they live

Modern oncology is changing at an unprecedented pace. Immunotherapies, antibody–drug conjugates (ADCs), bispecific antibodies and new targeted therapies are creating treatment opportunities that would have been unimaginable only a few years ago.

Cancer treatment is becoming increasingly personalised and tailored to the biological and molecular characteristics of each tumour, while overall survival is being extended for many people living with cancer.

Yet alongside this remarkable scientific progress, a critical question is emerging:

What does it really mean to live longer after — or with — cancer?

A recent Nature Medicine editorial, entitled “Oncology must confront hidden side effects”, highlights precisely this challenge. While cancer drug development is advancing at remarkable speed, the approaches used to record, assess and manage long-term treatment-related toxicities — and their impact on patients’ quality of life — have not evolved at the same pace.

When a “mild” side effect becomes a major burden

Therapeutic success can create a new reality: people are living longer, but some must also manage treatment-related adverse effects for months, years or even for the rest of their lives.

An adverse event classified clinically as low-grade is not necessarily insignificant to the person experiencing it.

A persistent rash, diarrhoea, stomatitis or other symptoms may substantially affect daily functioning, psychological wellbeing and social life when they continue over long periods.

Similarly, some immune-related adverse events associated with immune checkpoint inhibitors can become chronic, persist for years or even be irreversible.

This highlights an important limitation of the Common Terminology Criteria for Adverse Events (CTCAE), which are widely used to classify and grade treatment-related adverse events.

The duration of adverse events is not adequately reflected, while functional and psychological consequences may also remain outside traditional toxicity assessment.

As a result, what may be considered “manageable” according to conventional clinical criteria can feel very different to the patient living with it every day.

Quality of life cannot be an afterthought

A second important issue is the timing of quality-of-life evidence.

In some cases, quality-of-life findings are reported considerably later than the primary results of a clinical trial, and sometimes after a new drug has already been approved.

This means that patients making treatment decisions during the early years of a new therapy may not yet have a complete picture of how it could affect their daily functioning, emotional wellbeing and overall quality of life.

At the same time, the questionnaires and tools used to assess quality of life need to evolve continuously.

And this cannot happen without the direct involvement of patients themselves.

The experiences and priorities of people receiving treatment should form part of how treatment impact is assessed, rather than being treated as information that is added later.

The example of daraxonrasib

The Nature Medicine editorial highlights the pan-RAS inhibitor daraxonrasib as a telling example. The therapy has shown important survival benefits for patients with aggressive RAS-driven advanced pancreatic cancer, a setting in which treatment options have historically been limited.

At the same time, most patients experienced acneiform rash, with diarrhoea and stomatitis also reported as lower-grade treatment-related adverse events.

Full quality-of-life data — including information on daily functioning and emotional wellbeing — were not yet available because follow-up remained relatively short.

This example illustrates a much wider issue.

If we know that a therapy can significantly extend life, but we do not yet fully understand what that life will be like, an essential part of the information is missing from the conversation between patients and their healthcare teams.

This also has direct implications for informed consent.

Whenever evidence is available, patients need information not only about response rates and survival but also about the potential short- and long-term consequences of treatment for their everyday lives.

The same treatment is not experienced in the same way by everyone

The toxicity profile of a treatment is not identical for every patient.

It may vary according to the drug’s mechanism of action, a person’s physical condition, co-existing long-term conditions, genetic background and other individual characteristics.

Particular attention is needed for populations that have historically been excluded from, or underrepresented in, clinical trials, as their experiences of treatment-related toxicity may differ.

The editorial points, for example, to sex-related differences in adverse events associated with immunotherapy and racial disparities in adverse events observed with CAR-T cell therapy.

This makes real-world data particularly important.

Clinical trials remain fundamental to establishing the safety and efficacy of new treatments. However, broader use in everyday clinical practice may reveal treatment effects that were not fully captured in the populations included in initial studies.

One example is the bispecific antibody amivantamab in lung cancer, where the full extent and severity of some skin toxicities became clearer after a broader patient population was exposed to the treatment.

Moving beyond clinical silos

This changing landscape also demands a different approach to the organisation of cancer care.

The adverse effects of modern cancer therapies do not always fit within a single organ system or medical specialty.

Traditional clinical and disciplinary silos can limit the transfer of knowledge needed to identify, monitor and manage emerging toxicities effectively.

The response therefore needs to be interdisciplinary.

Collaborative networks, updated guidance, systematic reporting, dedicated registries and effective knowledge exchange are increasingly important so that new or rare adverse effects can be recognised early and managed appropriately.

Above all, the patient voice must be heard

Perhaps the most important change concerns how we define treatment success itself.

Survival remains a fundamental goal of oncology.

But it cannot be the only one.

We also need to understand whether people can work, move, sleep, eat, participate in family and social life, maintain as much independence as possible and manage the effects of treatment on their everyday lives.

In other words, we need to know not only how much time a treatment adds to life, but also what that time means to the person living it.

Patients should therefore not enter the process only at the end, as recipients of treatment.

Their perspectives need to be incorporated from the design of clinical trials and assessment tools through to post-approval monitoring and the real-world use of new cancer therapies.

From survival to living after — and with — cancer

Progress in oncology is undeniable, and it brings genuine hope.

The next challenge is to ensure that longer survival is accompanied by quality of life, functioning, meaningful information, participation and dignity.

Modern cancer care therefore needs to move beyond asking only:

“How much longer can this patient live?”

and give equal importance to another question:

“How will this person live during that additional time?”

For Kapa3, this discussion goes to the heart of truly person-centred cancer care: care that sees not only the disease and the treatment, but the person, their everyday life, their needs, their choices and the life that continues during and after cancer.

Source and references

Main source:
Nature Medicine. “Oncology must confront hidden side effects.” Volume 32, July 2026. Published online 8 July 2026. DOI: 10.1038/s41591-026-04554-9.

Barron CC et al. Journal for ImmunoTherapy of Cancer. 2023;11.
Gyawali B et al. Lancet Oncology. 2025;26–e89.
O’Reilly EM et al. New England Journal of Medicine. 2026. DOI: 10.1056/NEJMoa2605555.
Unger JM et al. Journal of Clinical Oncology. 2022;40:1474–1486.
Rayapureddy AK et al. Journal of Clinical Oncology. 2026;44.
Hines MR et al. Transplantation and Cellular Therapy. 2023;29:438.e1–438.e16.

find more s41591-026-04554-9

World Self-Care Day (July 24): The Importance of Self-Care on the Journey with Cancer.

July 24 has been designated as World Self-Care Day. This symbolic date (7/24) was chosen to remind us all of something very basic: that taking care of ourselves is a process that deserves to continue 24 hours a day, 7 days a week.

At the Cancer Patient Support Center, this day takes on a deeper and more meaningful significance. Self-care is not merely a luxury or a passing trend, but a valuable tool for physical, mental, and emotional empowerment—both for patients undergoing treatment and for their caregivers.

What does “self-care” mean?

According to the World Health Organization (WHO), self-care is defined as the ability of individuals, families, and communities to promote health, prevent disease, maintain well-being, and manage illness with or even without the support of a health professional.

This is an active commitment to ourselves, which includes:

1. Healthy daily habits: proper nutrition, adequate sleep, and moderate physical activity (always in consultation with your treating physician)

2. Prevention and responsibility: consistent medication adherence, regular preventive checkups, and following medical instructions.

3. Mental and emotional balance: recognizing personal boundaries, managing stress, accepting our emotions, and seeking help wherever and whenever we need it.

4. Health and health literacy: responsibly staying informed about our health status from reliable sources.

Self-Care in the Cancer Experience

For someone who has experienced cancer, self-care takes on a very personal character. It does not mean that “one must do everything on one’s own.” On the contrary, it is essential to:

• Listen to their body, without feeling guilty about the need for rest

• Take care of their emotional well-being. Allow themselves to feel every emotion—fear, fatigue, but also hope. Psychological support is considered one of the most important acts of self-care.

• Build a support network. It is absolutely essential to allow loved ones or specialized professionals to support them.

Caring for Caregivers

World Self-Care Day is equally dedicated to those who care for patients—family members, partners, and friends. People who stand by patients often tend to neglect their own needs, thereby driving themselves to physical and mental exhaustion. This day serves as a reminder that caring for caregivers is not selfish but an urgent necessity.

For caregivers to practice self-care in practice, they must first set boundaries, as they do not need to bear the entire burden alone. At the same time, it is important for them to acknowledge their emotions without judgment, accepting that fatigue, anger, and frustration are normal reactions. It is equally essential to set aside personal time. Fifteen to thirty minutes a day for a walk or to read a book can be beneficial. Finally, seeking psychological support is not a sign of weakness but an act of self-care.

The Cancer Patient Guidance Center is here for you

At K3, we believe that no one should have to walk this path alone. Self-care is strengthened when there is guidance, reliable information, and human support.

On this special day, let’s all take a step back from the fast pace of life and make our health and well-being a priority.

24 hours a day, 7 days a week: let’s take care of ourselves!

Memorandum of Understanding between the University of West Attica—specifically the Department of Occupational Therapy—and the NGO KAPA3.

On Tuesday, June 9, a meeting was held to sign a Memorandum of Understanding between the University of West Attica—specifically the Department of Occupational Therapy—and the NGO KAPA3.

The meeting was attended by the Rector of the University of West Attica, Panagiotis Kaldis Penelope Vlotinou, Assistant Professor in the Department of Occupational Therapy Evangelia Bista, co-founder of the organization, as well as representatives from both organizations, including the interdisciplinary team of KAPA3: Despoina Chrysostomou, Psychologist Katerina Georgiopoulou, Social Worker Yiannis Kontogiorgis, Psychologist, and Eleftheria-Irini Polyzoti, an intern from the Department of Social and Educational Policy, as well as students from the Occupational Therapy Department.

During the meeting, a constructive discussion took place regarding the prospects for cooperation between the two organizations, with the aim of developing joint actions and initiatives that will contribute to strengthening education, research, social contribution, and the connection between the academic community and society.

In this context, it was decided in April to jointly organize a major scientific conference, which will focus on an interdisciplinary and holistic approach to health, on combating social inequalities in healthcare, as well as on the management of chronic disease. The aim of this initiative is to raise community awareness, facilitate the exchange of expertise among professionals and scientific bodies, and disseminate scientific knowledge and information to the general public.

Special mention was made of the innovative work of KAPA3, the digital Health Navigator “Myrto,” a modern artificial intelligence tool currently under development and designed to support cancer patients, their families, and their caregivers. “Myrto” will function as a digital assistant (Chatbot) and Health and Rights Navigator, providing immediate, reliable, and personalized information on health, social welfare, rights, benefits, and available support services. The project aims to empower patients, improve their access to information, and reduce inequalities in health and social care through the use of digital technologies and artificial intelligence applications. The development of “Myrtos” represents a pioneering application of social artificial intelligence in the field of oncology care in Greece and is part of KAPA3’s strategy to promote innovation, accessibility, and the active participation of patients in managing their own health.

The meeting concluded in a particularly positive atmosphere of mutual appreciation and recognition. In this context, the Department of Occupational Therapy at the University of West Attica made a symbolic gesture toward the representative of KAPA3, Evangelia Bista, presenting her with a commemorative gift as a token of appreciation for her many years of valuable social contribution in the field of support for cancer patients. At the same time, as a gesture of hospitality and appreciation, the team was offered a specially produced wine, which is an original creation of the University of West Attica.

Newsletter Kapa3| June 2026,From survivorship to quality of life — from information to support — from technology to human-centred care.

May was a month of important developments, scientific outreach and service enhancement for Kapa3. From the new European scientific publication of the MELODIC project and educational participation in international networks, to the development of “Myrto”, the creation of a new Psychological Support Team and support through social and corporate initiatives, Kapa3 continues to bring together knowledge, technology, human care and social action.

Our mission remains focused on equal access for cancer patients and their caregivers to information, rights, services and meaningful support.

1. June: Cancer Survivors Month

June is dedicated to people living with and beyond cancer. Survivorship is not only the end of treatment; it is continuity, adaptation, reintegration, psychosocial support, quality of life and the right to care beyond therapy.

▸ EN: https://www.kapa3.gr/en/june-cancer-survivors-month-title-sep-sitename/

2. Kapa3 Introduces Its New Psychological Support Team

On the occasion of Mental Health Awareness Month and Cancer Survivors Month, Kapa3 introduces its new Psychological Support Team: a safe space for listening, support and empowerment for patients, survivors, caregivers and families.

▸ CONTACT US https://www.kapa3.gr/en/kapa3-introduces-its-new-psychological-support-team/

3. New MELODIC Scientific Publication on the Mental Health of Young Adults with Cancer

Mental health is an integral part of cancer care, particularly for young adults facing the complex challenges of a cancer diagnosis. Kapa3 contributes to the new scientific publication of the European MELODIC project, highlighting the educational needs of healthcare professionals.

▸ READ THE ARTICLE

4. Digital Health and Cancer Survivorship: Kapa3 at the INE-CSC 2026 Conference in Coimbra

Kapa3 participated in the INE-CSC 2026 Conference in Coimbra, contributing to the European dialogue on cancer survivorship, supportive care, digital health and participatory solutions that respond to the real needs of patients and caregivers.

▸ READ THE ARTICL Ehttps://www.kapa3.gr/en/participation-in-ca21152-implementation-network-europe-for-cancer-survivorship-care/

5. Co-creating Myrto: A Digital Health and Rights Navigator for Oncology Patients

Myrto is designed as a digital health and rights navigator — a Patient Empowerment e-Navigator — that goes beyond information provision to guide, support and evolve according to users’ real needs.

▸ READ THE ARTICLE https://www.kapa3.gr/en/myrto-health-navigator-oncology-patients-greece/

6. Learning by Doing: Participation in the European Service Learning 2.0: CoLab Programme

Kapa3 participated in the European programme Service Learning 2.0: CoLab, an initiative connecting academic knowledge with meaningful social action and highlighting collaboration between universities, civil society organisations and community actors.

▸ FIND OUT MOREhttps://www.kapa3.gr/en/learning-by-doing-participation-in-the-european-service-learning-2-0-colab-programme/

7. Alpha Bank and Its Employees Support Kapa3 through the Match for Good Initiative

Through the Match for Good initiative, Alpha Bank and its employees supported Kapa3, strengthening our mission to stand alongside people affected by cancer, their families and caregivers.

▸ FIND OUT MORE https://www.kapa3.gr/en/i-alpha-bank-kai-oi-ergazomenoi-tis-stirizoyn-to-kapa3-kai-tin-isotimi-prosvasi-stin-ypostirixi-ton-ogkologikon-asthenon/

8. 6 Awards for Kapa3 at the 4th Vouliagmeni Summer Crossing: Is There Such a Thing as a “Lonely Race”?

Kapa3 took part in the 4th Vouliagmeni Summer Crossing, sharing a strong message of participation, resilience, empowerment and solidarity. Even when a race seems individual, it does not have to be lonely.

Newsletter closing note

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Support our work and help us continue to provide information, guidance and support to patients and their families.

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June: Cancer Survivors Month

Survival is a victory — but care must continue

June is dedicated to people living with and beyond cancer. It is a month of recognition, hope and respect for every person who has faced a cancer diagnosis, completed treatment, continues treatment, or lives with cancer as a long-term condition.

Cancer survival is a major victory. However, for many people, it is not the end of the story. Life after cancer often brings a new reality: follow-up appointments, fear of recurrence, fatigue, emotional distress, changes in body image, work-related challenges, financial pressure, family adjustments and the need to rebuild everyday life with confidence and dignity.

Cancer Survivors Month reminds us that survivorship is not only about living longer. It is also about living better.

A cancer survivor is not only a person who has completed treatment and is disease-free. The term also includes people receiving maintenance treatment, people living with cancer as a chronic condition, and those who continue to experience the physical, emotional, social or economic consequences of the disease and its treatment.

In recent years, advances in early diagnosis, targeted therapies, immunotherapy, surgery, radiotherapy and supportive care have increased the number of people living many years after a cancer diagnosis. This is a major achievement for medicine, research and public health. At the same time, it creates a new responsibility: to ensure that survivorship care is organised, person-centred and accessible to all.

For many survivors, the end of active treatment is a moment of relief and gratitude. Yet it may also bring uncertainty. Some people feel that everyone around them expects them to “go back to normal”, while they are still trying to understand what has changed in their body, their emotions, their relationships and their daily life.

The fear of recurrence, anxiety before follow-up tests, persistent fatigue, pain, cognitive difficulties, changes in sexuality, emotional vulnerability and social isolation are real experiences for many people after cancer. These needs should not be underestimated. Survivors need space to speak, reliable information, access to professional support when needed, and connection with communities and organisations that understand their journey.

Long-term follow-up is also essential. Survivorship care should not focus only on recurrence. It should also include prevention, early recognition of late effects, management of treatment-related complications, support for mental health, healthy lifestyle guidance and personalised monitoring according to each person’s cancer type, treatment history, age and individual risk factors.

The message is not fear. The message is awareness, prevention and continuity of care.

Life after cancer is also about rights. It is about returning to work, accessing social benefits, understanding available services, managing financial toxicity, supporting caregivers, protecting dignity and ensuring equal access to care. Survivorship must be seen as a social, psychological and practical issue — not only a medical one.

At Kapa3, we see every day that cancer does not always end with the last treatment. It continues in the questions people ask about their rights, their next steps, their follow-up, their access to benefits, psychological support, work, family life and social reintegration.

This is why people living with and beyond cancer need holistic support. They need information, guidance, psychosocial care, access to rights and services, empowerment and continuity of care. No one should feel alone after treatment. No one should be left to navigate bureaucracy, uncertainty or lack of information without support.

Cancer Survivors Month invites us to change the way we talk about survival. We should not ask only: “Did the person survive cancer?” We should also ask:

Are they living with quality of life?
Do they have access to the care they need?
Do they know their rights?
Do they receive psychological and social support?
Can they return to work and daily life with dignity?
Is there a follow-up plan?
Is there someone to guide them when they do not know where to turn?

Cancer survival is a victory. But the real challenge is to turn this victory into a life with quality, safety, rights, support and hope.

At Kapa3, we continue to stand beside every person living with and beyond cancer. Through information, guidance, empowerment and human-centred support, we believe that care does not stop at treatment.

It continues in life.

Depression and Cancer Mortality: A Critical Link Across Major Cancer Types

Depression is a common but often underrecognized condition among cancer patients, affecting up to 20–30% of individuals diagnosed with the disease. Beyond its impact on quality of life, mounting evidence suggests that depression can significantly influence cancer outcomes, including survival. A recent meta-analysis of 65 cohort studies spanning colorectal, breast, lung, prostate, and mixed cancers provides compelling evidence that depression diagnosed after a cancer diagnosis is associated with a substantially increased risk of mortality.

The analysis revealed that patients with depression faced an 83% higher risk of dying from colorectal cancer, a 59% higher risk in lung cancer, a 74% higher risk in prostate cancer, and a 23% higher risk in breast cancer compared to non-depressed patients. Across mixed cancer types, depression increased the risk of cancer mortality by 38%. These findings underscore that the psychological burden of cancer is not merely an emotional challenge but a critical factor affecting survival outcomes.

Mechanisms Linking Depression and Cancer Outcomes

Depression may influence cancer progression through multiple biological and behavioral pathways. Biologically, depression is associated with chronic systemic inflammation, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, immune suppression, autonomic dysfunction, oxidative stress, and impaired DNA repair. Elevated pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), can contribute to tumor growth and metastasis. In older patients, depression may exacerbate age-related immune dysfunction, creating an environment more permissive to cancer progression.

Behaviorally, depression affects health-related actions and treatment adherence. Depressed patients are more likely to delay seeking medical care, adhere poorly to chemotherapy, radiotherapy, and hormonal therapies, and engage in unhealthy habits such as smoking, poor nutrition, and physical inactivity. Social isolation and reduced support systems further increase vulnerability, compounding the negative impact on survival.

Clinical Implications and Interventions

The strong association between depression and cancer mortality highlights the urgent need to integrate mental health care into routine oncology practice. Psychological interventions, such as cognitive-behavioral therapy (CBT), supportive-expressive therapy, and mindfulness-based approaches, have shown promise in reducing distress and improving adherence to cancer treatment. Pharmacological management, including selective serotonin reuptake inhibitors (SSRIs), may also support mental health and potentially influence cancer outcomes, though more research is needed to understand their role fully. Early identification and treatment of depressive symptoms should be considered a priority for oncologists, mental health professionals, and healthcare policymakers alike.

Limitations and Future Directions

While this meta-analysis provides robust evidence, several limitations should be noted. The observational nature of the studies prevents establishing causality, and differences in study design, depression assessment methods, and patient populations contribute to heterogeneity. Future research should explore longitudinal and randomized studies to clarify causal pathways and identify the most effective interventions to reduce depression-related mortality. Investigating the interactions between depression, inflammation, and cancer biology may also reveal targets for novel supportive therapies.

Depression is not just a psychological burden for cancer patients—it is a significant predictor of mortality across multiple cancer types. These findings call for systematic depression screening and tailored interventions as integral components of oncology care.

Organizations like Kapa3 play a vital role in supporting the mental health of cancer patients, offering resources and guidance that can improve both quality of life and treatment outcomes. Integrating psychological support into cancer care ensures that mental well-being is recognized as an essential part of the healing process.
In line with this mission, Kapa3 participates in MELODIC, a new European initiative dedicated to supporting the mental health of young adults (18–30 years old) living with or beyond cancer.

Read the original article here

The Power of Social Support in Cancer Care

Why connection is as vital as treatment

Mental health professionals consistently emphasise the value of a strong social support network. Social support is among the strongest predictors of emotional well-being and overall quality of life. It refers to the extent to which our social and emotional needs are met through the people and communities around us, such as family, friends, colleagues, and groups that share our values and experiences.

Group interventions, for example, have been shown to reduce psychological stress by providing individuals with chronic illnesses the opportunity to connect and share experiences (Jackson et al., 2019). Studies have found that cancer patients who felt more supported by family, friends, or their community experienced less distress, coped more effectively, and had a greater sense of control during treatment. Tangible support, in particular, was more significant for older patients, who may face greater physical challenges due to age or disability (Ahmad et al., 2013).

Furthermore, social support fosters optimism and resilience, which are key factors that help patients adapt to illness. By strengthening hope and inner confidence, social connections help protect against anxiety and depression, acting as a buffer against the emotional impact of stress (Ruiz-Rodríguez et al., 2022).

But what comes first — support or coping? The systematic review by Bottaro and colleagues (2023) suggests the relationship is bidirectional: people who receive strong support cope better, and those who cope better are more likely to seek and maintain strong relationships. It’s a cycle of connection that reinforces recovery.

The source of support also plays a crucial role. Patients often view family, friends, and partners as the most important sources of support for coping with diagnosis and treatment. However, when the type of support offered doesn’t align with the patient’s needs, it can feel less meaningful or even unhelpful.

While loved ones form the core of emotional care, healthcare professionals are often the first and most consistent source of reassurance. According to the literature, patients who feel heard, respected, and well-informed by their medical team cope more effectively and experience less anxiety. Ruiz-Rodríguez and colleagues highlight that optimism and resilience grow when medical staff communicate openly and offer encouragement. Compassionate communication from healthcare providers strengthens patients’ ability to manage their illness, creating a positive feedback loop between support and wellbeing (Bottaro et al., 2023).

At Kapa3, we witness this truth daily. Through our community programs, research, and advocacy, we work to create environments where no one faces cancer alone. Social support is not only emotional, it’s practical, cultural, and profoundly human. Healing doesn’t happen only in hospitals; it happens in homes, workplaces, and communities.

References

Ahmad, M., Khan, M. A., & Shirazi, M. (2013). Perception of Social Support by Cancer Patients. International Journal of Psychology and Behavioral Sciences, 3(5), 115–122. https://doi.org/10.5923/j.ijpbs.20130305.01

Bottaro, R., Craparo, G., & Faraci, P. (2023). What is the direction of the association between social support and coping in cancer patients? A systematic review. Journal of Health Psychology, 28(6), 135910532211311. https://doi.org/10.1177/13591053221131180

Jackson, M., Jones, D., Dyson, J., & Macleod, U. (2019). Facilitated group work for people with long-term conditions: A systematic review of benefits from studies of group-work interventions. British Journal of General Practice, 69(682), 363–372. https://doi.org/10.3399/bjgp19x702233

Ruiz-Rodríguez, I., Hombrados-Mendieta, I., Melguizo-Garín, A., & Martos-Méndez, M. J. (2022). The importance of social support, optimism and resilience on the quality of life of cancer patients. Frontiers in Psychology, 13. https://doi.org/10.3389/fpsyg.2022.833176

Article by: Despina Chrysostomidou, Psychologist for Kapa3 Research Insights

Continuing the Journey: Holistic Body and Mind Care with Kapa3 and the University of the Peloponnese

After the first round of meetings held in April (see the related article here), focusing on Nutritional Guidance and Experiential Psychological Support, Kapa3 and the University of the Peloponnese continue their collaboration with a new series of experiential workshops dedicated to the holistic care of body and mind.

The meetings are open to people living with cancer, caregivers, and healthcare professionals — to anyone seeking a space for genuine communication, understanding, and empowerment.

In this new cycle, mental health and nutrition are approached as two sides of the same care.

In the mental health sessions, participants learn to recognize and manage challenging emotions such as anxiety or fear, strengthen their resilience, and cultivate a deeper connection with themselves and others.

At the same time, the nutrition sessions explore how balanced and mindful eating can support the body, enhance energy and mood, and become an act of self-care and self-respect. Food is not only a necessity but also a way to show love — to the body, the soul, and to life itself.

The meetings are held online and are based on dialogue, experiential learning, and the sharing of personal experiences. Everyone participates at their own pace, in a warm environment of acceptance and trust.

To express your interest: Registration Form for the Support Group for People with Cancer

Text/adaptation: Ifiyenia for Kapa3

October – Breast Cancer Awareness Month

October is internationally recognized as Breast Cancer Awareness Month, a time dedicated to education, prevention, and support for everyone affected by the disease. Breast cancer remains the most common cancer among women worldwide, yet early diagnosis and advances in treatment have significantly improved both quality and length of life.

The event began in 1985 as a week-long awareness campaign by the American Cancer Society, in partnership with Imperial Chemical Industries, a British company that made tamoxifen. The campaign eventually grew into a month-long event.

The core message of this month is simple but crucial: awareness saves lives. Regular mammograms, self-examinations, and timely medical advice when suspicious signs appear are the most powerful tools for prevention and early detection. International studies show that women who participate in screening programs are more likely to be diagnosed at an early stage, allowing for more effective and less invasive treatment.

However, October is not just about medical tests. It is a month that highlights the importance of psychosocial support and solidarity. Breast cancer affects not only the body but also the mind and spirit. Women – and men – facing this diagnosis need a supportive network of family, friends, healthcare professionals, and organizations to guide, encourage, and stand by them every step of the way.

The Kapa3 Cancer Guidance Center joins the international community in emphasizing the value of accurate information and equitable access to healthcare services. Through informative articles, prevention guides, and psychological support, our goal is to stand by every person in need, providing reliable knowledge and meaningful assistance.

Breast Cancer Awareness Month is more than a campaign: it is a reminder that life can be won when prevention, education, and solidarity become part of our daily practice. October calls on all of us to raise our voices, promote screening, and embrace those fighting their own battles—because no one should face cancer alone.