Category: Kapa3

When Art Meets Science: How CREATE Platform May Strengthen Emotional Regulation in Cancer Care

At Kapa3, we recognize that cancer affects far more than the body, challenging the emotions, sense of self, relationships, and quality of life of those suffering. Despite the high prevalence of co-occuring mental health issues such as anxiety and depression, access to mental health services remains limited. This gap between patient needs and healthcare provisions is precisely what motivated us to help develop CREATE, an innovative digital platform designed to support emotional resilience through a powerful combination of art, technology, and emotional engagement (Ladas et al., 2025).

The CREATE (Creative and Resilience through Arts, Technology, and Emotions) platform uses computerised cognitive training (CCT) designed to enhance emotional regulation by integrating working memory training, engagement with famous artwork, and creative emotional expression. Unlike other platforms, it only targets one cognitive function: working memory. Evidence suggests that focusing on a single cognitive function is more effective than targeting multiple ones. Working memory in particular has been found to influence emotional regulation, a skillset with established benefits for anxiety and depression.

CREATE therefore introduces a unified framework that addresses cognitive function, emotional expression, and biological influences such as sleep quality and dopamine activity. Such digital health solutions are increasingly recognized as promising alternatives to standard psychotherapy, offering greater accessibility and affordability while still capable of reducing symptoms of depression and anxiety.

Findings from the pilot study on CREATE were very promising; the participants found the platform easy to use and enjoyable, and showed increased emotional and creative engagement. Although this early research focused on feasibility and validity rather than therapeutic effectiveness, initial findings indicate improvements in emotional regulation. Importantly, the study demonstrated positive relationships between working memory, emotional regulation, and expression of emotion, while also suggesting that sleep and dopamine may mediate these effects.

These insights highlight the importance of lifestyle and biological data in developing personalized digital mental health tools. It is well established in neuroscience that working memory plays a central role in emotional regulation. A stronger working memory allows individuals to better cope with distressing thoughts, shift their attention, and respond more calmly to challenges. For people living with cancer, supporting these cognitive and emotional capacities makes daily life more manageable. Improved thinking skills can facilitate treatment adherence, informed decision-making, and a more effective management of the emotional turbulence that often accompanies illness.

The study relied on a convenience sample made up mostly of cancer-related healthcare professionals, and only one cancer survivor participated. To address this limitation, the next phase of research will focus entirely on cancer patients and survivors. Their unique challenges, including cancer-related fatigue and treatment-related cognitive changes, will be central to refining the platform and ensuring that CREATE is tailored to the needs of those it aims to benefit the most. This creates not only a more impactful intervention but also empowers patients to have a voice in shaping the future of supportive cancer care.

As we look ahead, CREATE offers a hopeful vision for digital mental-health support. It is scalable, affordable, and adaptable, making it especially valuable for people who lack access to mental health care. Intervening early and supporting emotional well-being throughout treatment and survivorship may reduce the long-term strain on healthcare services associated with mental health conditions.  As cancer treatment continues to evolve, we must make sure that psychological care develops along with it. And CREATE does just that.

Read the full study

References

Ladas, A. I., Katsoridou, C., Gravalas, T., Klados, M. A., Stravoravdi, A. S., Tsompanidou, N., Fragkedaki, A., Bista, E., Chorafa, T., Petrovic, K., Vlotinou, P., Tsiakiri, A., Papazisis, G., & Frantzidis, C. A. (2025). Creativity and REsilience Through Arts, Technology and Emotions: A Pilot Study on the Feasibility and Validity of the CREATE Platform. Brain Sciences, 15(11), 1171.

‌Article by Despina Chrysostomidou, Psychologist, for Kapa3 Research Insights

4 November: International Stress Awareness Day

Stress is a natural response to life’s challenges and changes. It helps us respond, adapt, and stay motivated. But when it becomes prolonged, it can turn into an invisible, exhausting companion that affects every aspect of daily life — body, mind, relationships, and mood. International Stress Awareness Day (4 November) is a reminder to pause, take a deep breath, and acknowledge that mental health deserves the same care as physical health.

In Greece, the mental health burden remains significant. According to the OECD (2023, Country Health Profile), around 6% of the population experiences anxiety disorders, while 7% report symptoms of depression. At the same time, more recent studies in younger age groups show that stress affects a much larger proportion: in a 2020 survey of university students, high levels of moderate to severe stress and extreme anxiety were reported. Additionally, international daily stress measurements indicate that about 58% of Greeks felt stress the previous day, placing the country among the highest in Europe and globally. These figures highlight that anxiety touches a substantial part of the population and significantly impacts daily life, emphasizing the importance of awareness and support.

Stress can manifest in multiple ways: rapid heartbeat, difficulty concentrating, insomnia, irritability, or simply feeling like there’s “never enough time.” Too often we dismiss it as “part of life.” But caring for our mind and emotions is not a luxury — it is a responsibility to ourselves. Support from mental health professionals, physical activity, connection with nature, music, art, or even a simple conversation with someone we trust can become small breaths of balance.

People living with chronic illnesses, including cancer, often face heightened stress. Anxiety about treatment, uncertainty about the future, and the physical impact of disease can intensify tension and worry. Recognizing and validating this stress is essential, as support through networks, counseling, and accessible resources can make a meaningful difference.

At Kapa3, we believe no one should face stress or illness alone. Through our programs, initiatives, and community, we offer guidance, emotional support, and practical help, highlighting that mental well-being is a shared journey and empathy is key.

Today is more than a reminder of the risks of stress. It is an invitation to speak openly without fear or shame, to create space for understanding and acceptance. Let’s learn to listen to our bodies and minds, recognize the signs, and seek help when needed. Calmness is not a luxury — it is a right for everyone.

Read more in previous articles of Kapa3: Article1, Article2, Article3

Sources:

OECD (2023), Country Health Profile: Greece
Stress, Anxiety and Depression Prevalence among Greek University Students during the COVID-19 Pandemic (2023, PLOS ONE / PMC)
Gallup Global Emotions Report 2024 – Ελλάδα: Daily Stress Measurement (58%)

Text/adaptation: Ifiyenia Anastasiou for Kapa3

October 25 – World Breast Cancer Awareness Day

October 25 has been established as World Breast Cancer Awareness Day, a day dedicated to raising awareness, promoting prevention, and supporting people living with this disease. Breast cancer is the most commonly diagnosed cancer among women worldwide, affecting approximately 2.3 million women each year, with 670,000 deaths, while in Greece around 6,000 new cases are diagnosed annually (Source: Globocan 2025). These are not just numbers—they are mothers, sisters, daughters, and friends who deserve hope and dignity.

Survival chances depend on access to early detection and effective treatment: in high-income countries, the five-year survival rate exceeds 90%, while in countries such as India it is 66% and in South Africa only 40%. These inequalities highlight the urgent need for coordinated international action, as incidence and mortality are projected to rise by 40% by 2050 if current trends continue.

Breat scancer does not affect only women—around 1% of diagnoses occur in men, a fact often overlooked. Awareness and education must be inclusive so that no one is left unprotected.

The WHO Global Breast Cancer Initiative, established in 2021, works with countries to reduce breast cancer mortality by strengthening health systems and facilitating access to diagnosis and treatment.

At the same time, psychosocial support for patients and their families is crucial, as a diagnosis affects all aspects of life, from work to daily routines and mental well-being.

International Breast Cancer Awareness Day also calls on communities, health organizations, and authorities to collaborate to improve access to screening and treatment services. Raising awareness about risk factors—such as genetics, age, and lifestyle—and promoting healthy habits helps prevent the disease and reduce health inequalities.

Every individual can contribute: schedule a mammogram, remind friends to do the same, support nonprofit organizations, or participate in awareness activities. Even small gestures, like wearing a pink ribbon or sharing reliable information on social media, make a difference.

At Kapa3, we believe that every woman and person living with cancer deserves support, knowledge, and access to high-quality treatments. Through initiatives in awareness, social support, and empowerment, our goal is to build a society where no life is endangered by lack of information, resources, or care, and wher

e hope and solidarity become powerful allies in the fight against the disease.

Read more on breast cancer:

https://www.kapa3.gr/en/raising-the-standards-europe-s-qa-scheme-for-breast-cancer-services/

Understanding Breast Cancer Risk Factors: What You Can and Can’t Change

October – Breast Cancer Awareness Month

Sources: https://gco.iarc.fr/en

https://www.who.int/initiatives/global-breast-cancer-initiative

https://www.who.int/news-room/fact-sheets/detail/breast-cancer

Text/adaptation: Ifiyenia Anastasiou for Kapa3

EGFR: An “Old Target” Gaining New Life in Cancer Research

When science moves forward step by step

Progress in oncology does not always come with dramatic announcements. Often, it is found in studies that show small but meaningful steps. One such case is a recent review in JAMA Oncology exploring new targeted therapies for head and neck cancer — a type of cancer often linked to smoking, alcohol consumption, or HPV infection. At Kapa3, we closely follow these developments to keep patients and their families responsibly informed,

Researchers focused on a protein called EGFR (Epidermal Growth Factor Receptor). Approximately 90% of patients with this type of cancer show overexpression of the protein, making it an attractive target for therapy. In the past, drugs such as cetuximab attempted to “block” EGFR activity, but results were limited. Patients experienced modest improvements without a significant increase in survival.

The new generation of research goes a step further. Combination therapies are being explored, such as targeting EGFR alongside immunotherapy (e.g., pembrolizumab), which strengthens the body’s defense against cancer cells. In early studies, this combination showed response rates around 45% and a median survival of approximately 18 months in patients for whom previous treatments had failed — results that, while not dramatic, are considered encouraging for this disease.

Scientists now understand that the success of targeted therapy depends on multiple factors. In many patients, cancer cells eventually develop resistance, “learning” to bypass the drug’s effect. In addition, cancers linked to HPV appear to behave differently from those that are not, opening new avenues for more personalized approaches.

Research is also focusing on identifying biomarkers — molecular indicators that can show which patients are most likely to benefit from a particular therapy. If these tools prove reliable, they could lead to more targeted, effective, and safer treatments in the future.

At the same time, newer forms of drugs are being tested, such as bispecific antibodies and antibody–drug conjugates, which aim to target cancer cells with greater precision. All of these efforts are still in early clinical trial stages, aiming to improve efficacy and reduce side effects.

The key message of this research is not that a “new drug that beats cancer” has been found, but that science continues to search, test, and learn. Every small step, every percentage of improvement, every new idea paves the way for future progress.

For people living with cancer — and their families — hope lies not only in major breakthroughs and new treatments but also in the certainty that thousands of researchers around the world are tirelessly working to make each next step a little closer to life. Because in science, as in life, progress is often measured not in leaps but in steady, human steps. At Kapa3, we are committed to sharing this news in a clear and useful way for everyone.

Read the review here

Sources:

Hwang W. et al. “Emerging EGFR-Targeted Therapy in Head and Neck Cancer: A Review.” JAMA Oncology (2025).
World Health Organization – Cancer Research Updates

Text/adaptation: Ifiyenia for Kapa3

Continuing the Journey: Holistic Body and Mind Care with Kapa3 and the University of the Peloponnese

After the first round of meetings held in April (see the related article here), focusing on Nutritional Guidance and Experiential Psychological Support, Kapa3 and the University of the Peloponnese continue their collaboration with a new series of experiential workshops dedicated to the holistic care of body and mind.

The meetings are open to people living with cancer, caregivers, and healthcare professionals — to anyone seeking a space for genuine communication, understanding, and empowerment.

In this new cycle, mental health and nutrition are approached as two sides of the same care.

In the mental health sessions, participants learn to recognize and manage challenging emotions such as anxiety or fear, strengthen their resilience, and cultivate a deeper connection with themselves and others.

At the same time, the nutrition sessions explore how balanced and mindful eating can support the body, enhance energy and mood, and become an act of self-care and self-respect. Food is not only a necessity but also a way to show love — to the body, the soul, and to life itself.

The meetings are held online and are based on dialogue, experiential learning, and the sharing of personal experiences. Everyone participates at their own pace, in a warm environment of acceptance and trust.

To express your interest: Registration Form for the Support Group for People with Cancer

Text/adaptation: Ifiyenia for Kapa3

World Osteoporosis Day

Every year on October 20th, the world observes World Osteoporosis Day, a day dedicated to raising awareness about osteoporosis, a condition that weakens bones and increases the risk of fractures. First established by the International Osteoporosis Foundation (IOF) in 1996, the day serves to educate the public on the importance of bone health, early diagnosis, and prevention strategies, highlighting that osteoporosis is not just an age-related issue but a concern affecting millions globally, including younger adults.

Osteoporosis is particularly significant for cancer patients, as both the disease and certain cancer treatments can compromise bone health. Therapies such as hormone deprivation for breast or prostate cancer, long-term steroid use, or chemotherapy may accelerate bone loss, increasing the likelihood of fractures, chronic pain, and reduced mobility. For patients already facing the physical and emotional challenges of cancer, maintaining bone strength becomes essential not only for quality of life but also for their overall recovery and long-term well-being.

In Greece, osteoporosis is a prevalent concern. According to the International Osteoporosis Foundation, approximately 22.3% of women and 6.9% of men aged 50 years or more were estimated to have osteoporosis in 2019. This condition leads to significant health burdens, with 684,000 new fragility fractures reported in 2019 alone. The economic impact is also notable, with the direct cost of incident fractures amounting to €694.7 million in 2019.

For cancer patients, the risk is even higher. Studies indicate that following adjuvant chemotherapy, cancer patients are more likely to develop osteopenia and osteoporosis, affecting up to two-thirds of males and more than half of females. This underscores the importance of proactive bone health management in oncology care.

At Kapa3, we are committed to supporting cancer patients in maintaining optimal bone health. While we do not provide direct medical interventions, we emphasize education, guidance, and psychological support for those navigating health challenges. By promoting awareness of conditions like osteoporosis, especially in the context of cancer care, we aim to empower patients, caregivers, and healthcare providers with knowledge and practical strategies to maintain bone health and prevent complications.

World Osteoporosis Day is a reminder that prevention, timely diagnosis, and lifestyle measures—including nutrition, regular weight-bearing exercise, and appropriate supplementation—play a crucial role in reducing the burden of osteoporosis. Health systems, patient organizations, and communities can work together to ensure that vulnerable populations, including cancer patients, have access to accurate information, screening services, and supportive care.

As we honor this day, Kapa3 encourages everyone to consider bone health as part of comprehensive patient care. By increasing awareness and fostering informed choices, we can help individuals live stronger, safer, and healthier lives, even in the face of serious illness. Osteoporosis may silently weaken bones, but knowledge, prevention, and support can strengthen patients’ resilience and quality of life.

For more information, please refer to the International Osteoporosis Foundation’s report on osteoporosis in Greece: IOF Greece Report.

 

October 17 – International Day for the Eradication of Poverty

October 17 has been established by the United Nations as the International Day for the Eradication of Poverty, a day dedicated to raising awareness and taking action against a phenomenon that continues to affect millions of people worldwide. The observance began in 1987, when thousands of citizens gathered in Paris to honor the victims of extreme poverty and advocate for a more just and equitable future for all.

Poverty is not only about lack of income—it affects access to education, healthcare, housing, employment, and mental well-being. For people living with serious or chronic illnesses, such as cancer, financial insecurity further complicates daily life, limiting access to treatments, medications, and supportive services.

According to the latest Hellenic Statistical Authority data (Income and Living Conditions Survey 2024), 26.9% of Greece’s population—approximately 2.74 million people—is at risk of poverty or social exclusion, an increase compared to the previous year. Greece ranks second in the EU after Bulgaria, highlighting the difficulty households face in coping with inflation, the energy crisis, and limited social protection.

Globally, according to the United Nations World Social Report 2025, over 690 million people live in extreme poverty (less than $2.15 per day), while 1.1 billion experience multidimensional poverty, lacking access to healthcare, education, and a decent standard of living. Social and economic crises, combined with climate change, disproportionately impact vulnerable households, increasing inequalities and reducing opportunities for stable recovery.

The International Day for the Eradication of Poverty also emphasizes the role of communities and decision-makers in creating inclusive systems. Addressing social determinants of health, ensuring access to essential services, and empowering vulnerable groups are critical to reducing inequalities and improving quality of life. By working together—health professionals, social organizations, and civil society—we can create a world where those facing illness are not further burdened by poverty.

At Kapa3, we firmly believe that access to quality healthcare and decent living conditions are fundamental human rights. Poverty and health are interconnected—the one can easily amplify or worsen the other. Through awareness, empowerment, and social support initiatives, we strive to contribute to a society where no one is deprived of the care they deserve, regardless of income. 

Read more: https://www.un.org/en/observances/day-for-eradicating-poverty

https://www.statistics.gr/documents/20181/3d7d2251-2302-9023-5280-a1d962c3a7a5

Kapa3 honored with Gold Award at the Hellenic Responsible Business Awards 2025 NGO of the Year – Health and Social Welfare

A major distinction was awarded to the Cancer Guidance Center – Kapa3, which received the Gold Award in the category “NGO of the Year – Health and Social Welfare” at the Hellenic Responsible Business Awards 2025.

Celebrating its 10th anniversary, the awards recognize organizations and initiatives that promote sustainable entrepreneurship and social impact. The ceremony took place on October 14th at the Anais Club, under the auspices of the Ministry of Development, the Ministry of Environment and Energy, SEV-VIAN, and SETE.

This award highlights Kapa3’s consistent commitment to holistic cancer care, offering free psychosocial guidance, empowerment programs, educational activities, social reintegration initiatives, and innovative digital tools.

Evangelia Bista, President and Founder of Kapa3, stated:

“More than a success, this distinction is a reminder of our values — collaboration, quality, dedication, empathy, and innovation. I am deeply grateful for this exceptional team whose integrity, tireless effort, and shared vision make a difference for our patients. This award belongs to them.”

Since its establishment, Kapa3 has supported more than 10,000 patients and families, while over 1,000 new users visit its website daily for reliable information and guidance. Through scientific evidence, digital innovation, and strong partnerships with public and European stakeholders, Kapa3 promotes a new model of cancer care based on equality, dignity, and inclusion.

As Ms. Bista noted:

“One swallow can make a spring — if you believe in it. And at Kapa3, we’ve been believing it for years, against all odds. We believe.”

“This recognition gives us renewed energy to pursue our mission with dedication, to remain on the frontlines for patients and their families, and to commit every day to improving the support we provide.”

Melodic, A New European Project Supporting the Mental Health of Young Adults with Cancer

At Kapa3, we know that healing goes far beyond the body. A cancer diagnosis in young
adulthood — just as life is beginning to unfold — often leaves deep emotional marks. That’s
why we’re proud to participate in MELODIC, a new European initiative dedicated to
supporting the mental health of young adults (18–30) living with or after cancer.

The project Melodic brings together 13 partners from 6 European countries, including patient organizations, universities, and healthcare experts. Coordinated by Turku University of Applied Sciences (Finland), MELODIC aims to co-design innovative digital tools, peer
support models, and educational workshops that reflect the actual needs and voices of
young people affected by cancer.

Kapa3 joined the project in 2024, and our role is to bring Greek patients’ perspectives to
the table while also ensuring that everything we co-create reaches the people who need it
most — especially here in Greece.

We believe that mental well-being is not a luxury, but a vital part of cancer care. Over the next two years, we’ll be working closely with survivors, caregivers, professionals, and youth groups to build safe spaces for expression, support, and growth.

Want to learn more? Visit our website and check out the new MELODIC subpage to see how
we’re working to make a difference — and how you can get involved.

Together, we can make mental health care more humane, inclusive, and empowering.
Because no one should face cancer — or life after it — alone.

Read more on Melodic project: Melodic Project Mental Health on YAC

 

“Kapa3–University Research Lab Collaboration Honored at the Bravo Sustainability Dialogue & Awards 2024”

The University Research Laboratory “Care of Adult Cancer Patients” of the Department of Nursing at the International Hellenic University (IHU), in collaboration with Kapa3, was honored at the Bravo Sustainability Dialogue & Awards 2024 for its contribution to supporting oncology patients and their families.

The award ceremony took place on December 2, 2024, at the Basil & Elise Goulandris Foundation, under the auspices of the Quality Net Foundation. The award was received by Maria Lavdaniti, Director of the Laboratory, together with Evangelia Bista, Development Manager of Kapa3.

The initiative was recognized under the Society pillar, specifically within the thematic category “Quality of Life & Volunteering Actions”, highlighting the importance of academic outreach, as well as the training and hands-on engagement of final-year students and graduates in real-world settings.

Kapa3 played a key role in the development and promotion of the initiative, placing strong emphasis on strengthening social innovation in the health sector. Its core objective was to improve the quality of life of patients and their families through meaningful, community-focused interventions.

The Quality Net Foundation, a non-profit organization promoting sustainable development in Greece since 1997, through the Bravo Sustainability Dialogue & Awards institution, showcases initiatives that support a sustainable future, in collaboration with organizations, businesses, local authorities, and civil society.

The Kapa3 team would like to warmly thank the International Hellenic University for the collaboration and the Quality Net Foundation for recognizing this important initiative, which reaffirms our commitment to developing innovative solutions that promote sustainability and social cohesion.

View photo material from the event

 

With kind regards,
On behalf of the entire Kapa3 team

Translation: Ifiyenia Anastasiou for Kapa3