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Mindfulness-Based Stress Reduction (MBSR) for Stress Relief

Mindfulness-Based Stress Reduction (MBSR) is a program developed by Professor Jon Kabat-Zinn at the University of Massachusetts Medical School, designed to help individuals focus on the present moment by observing thoughts, emotions, and bodily sensations with acceptance and without judgment. The program includes guided meditations, mindful movement exercises (such as yoga), breathing practices, and body scans, promoting mental calm, emotional regulation, and stress reduction.

As expected, this approach has been applied to reduce symptoms and improve quality of life in cancer patients. A recent systematic review published in BMC Psychology in November 2024 examined the effectiveness of MBSR in breast cancer patients, focusing on outcomes such as anxiety, depression, fatigue, quality of life, post-traumatic growth (PTG), fear of recurrence, pain, stress, and sleep.

The review included 15 randomized studies with a total of 1,937 participants. Results showed that the eight-week program significantly reduced anxiety and depression and improved quality of life compared to a six-week program or usual care. Additionally, post-traumatic growth increased and remained elevated even three months after completing the program. Fatigue decreased at the end of the program, though no statistically significant difference was found at the three-month follow-up. The method did not show significant effects on pain, stress, fear of recurrence, or sleep compared to usual care. Nevertheless, MBSR remains a powerful tool for psychological support.

At Kapa3, we believe that mindfulness can be a valuable aid for those who need it, and the results of this systematic review highlight MBSR’s value as a safe and effective intervention for the psychological support of patients.

Researchers note that a longer program duration allows participants to internalize MBSR practices and develop positive coping strategies. MBSR focuses on conscious attention to the present, with patience, acceptance, and a non-judgmental stance, helping regulate emotions and reduce negative thoughts related to the illness. Regular practice, especially in an eight-week program, appears to enhance positive outcomes, improving both psychological well-being and patients’ perception of their lives.

Depression and Cancer Mortality: A Critical Link Across Major Cancer Types

Depression is a common but often underrecognized condition among cancer patients, affecting up to 20–30% of individuals diagnosed with the disease. Beyond its impact on quality of life, mounting evidence suggests that depression can significantly influence cancer outcomes, including survival. A recent meta-analysis of 65 cohort studies spanning colorectal, breast, lung, prostate, and mixed cancers provides compelling evidence that depression diagnosed after a cancer diagnosis is associated with a substantially increased risk of mortality.

The analysis revealed that patients with depression faced an 83% higher risk of dying from colorectal cancer, a 59% higher risk in lung cancer, a 74% higher risk in prostate cancer, and a 23% higher risk in breast cancer compared to non-depressed patients. Across mixed cancer types, depression increased the risk of cancer mortality by 38%. These findings underscore that the psychological burden of cancer is not merely an emotional challenge but a critical factor affecting survival outcomes.

Mechanisms Linking Depression and Cancer Outcomes

Depression may influence cancer progression through multiple biological and behavioral pathways. Biologically, depression is associated with chronic systemic inflammation, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, immune suppression, autonomic dysfunction, oxidative stress, and impaired DNA repair. Elevated pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), can contribute to tumor growth and metastasis. In older patients, depression may exacerbate age-related immune dysfunction, creating an environment more permissive to cancer progression.

Behaviorally, depression affects health-related actions and treatment adherence. Depressed patients are more likely to delay seeking medical care, adhere poorly to chemotherapy, radiotherapy, and hormonal therapies, and engage in unhealthy habits such as smoking, poor nutrition, and physical inactivity. Social isolation and reduced support systems further increase vulnerability, compounding the negative impact on survival.

Clinical Implications and Interventions

The strong association between depression and cancer mortality highlights the urgent need to integrate mental health care into routine oncology practice. Psychological interventions, such as cognitive-behavioral therapy (CBT), supportive-expressive therapy, and mindfulness-based approaches, have shown promise in reducing distress and improving adherence to cancer treatment. Pharmacological management, including selective serotonin reuptake inhibitors (SSRIs), may also support mental health and potentially influence cancer outcomes, though more research is needed to understand their role fully. Early identification and treatment of depressive symptoms should be considered a priority for oncologists, mental health professionals, and healthcare policymakers alike.

Limitations and Future Directions

While this meta-analysis provides robust evidence, several limitations should be noted. The observational nature of the studies prevents establishing causality, and differences in study design, depression assessment methods, and patient populations contribute to heterogeneity. Future research should explore longitudinal and randomized studies to clarify causal pathways and identify the most effective interventions to reduce depression-related mortality. Investigating the interactions between depression, inflammation, and cancer biology may also reveal targets for novel supportive therapies.

Depression is not just a psychological burden for cancer patients—it is a significant predictor of mortality across multiple cancer types. These findings call for systematic depression screening and tailored interventions as integral components of oncology care.

Organizations like Kapa3 play a vital role in supporting the mental health of cancer patients, offering resources and guidance that can improve both quality of life and treatment outcomes. Integrating psychological support into cancer care ensures that mental well-being is recognized as an essential part of the healing process.
In line with this mission, Kapa3 participates in MELODIC, a new European initiative dedicated to supporting the mental health of young adults (18–30 years old) living with or beyond cancer.

Read the original article here

World Day for Organ Donation and Transplantation – October 28

October 28 is not only a day of national remembrance in Greece; it’s also the World Day for Organ Donation and Transplantation — a day dedicated to the second chance life can offer. A reminder that generosity does not end with us but continues through those who choose to give hope.

Organ donation is one of the most powerful expressions of solidarity and humanity. Each donation can save or transform up to seven lives — people who are waiting for a heart, liver, kidney, lungs, or other vital organs to survive. Yet, the numbers show that this gift of life is still far too rare. According to the Hellenic Transplant Organization (EOM), only about 8 organ donors per million population were recorded in Greece in 2023, compared to an EU average of 18 (EOM, 2023).

The gap between the need and availability of organs remains a pressing issue. Thousands of patients across Europe spend years on waiting lists, while many never get the chance for a transplant. Raising awareness, dispelling myths, and encouraging conversation within families are crucial steps toward change.

Becoming an organ donor means choosing to leave a legacy of life. It’s a selfless act that connects us beyond time, offering a heartbeat, a breath, or a new beginning to someone else.

Because when one life ends, another can begin — and that may be the most profound act of love there is.

Sources:

Hellenic Transplant Organization (EOM) here

European Directorate for the Quality of Medicines & HealthCare (EDQM) – Organ donation and transplantation statistics here

Text/Adaptation: Ifiyenia Anastasiou for Kapa3

EGFR: An “Old Target” Gaining New Life in Cancer Research

When science moves forward step by step

Progress in oncology does not always come with dramatic announcements. Often, it is found in studies that show small but meaningful steps. One such case is a recent review in JAMA Oncology exploring new targeted therapies for head and neck cancer — a type of cancer often linked to smoking, alcohol consumption, or HPV infection. At Kapa3, we closely follow these developments to keep patients and their families responsibly informed,

Researchers focused on a protein called EGFR (Epidermal Growth Factor Receptor). Approximately 90% of patients with this type of cancer show overexpression of the protein, making it an attractive target for therapy. In the past, drugs such as cetuximab attempted to “block” EGFR activity, but results were limited. Patients experienced modest improvements without a significant increase in survival.

The new generation of research goes a step further. Combination therapies are being explored, such as targeting EGFR alongside immunotherapy (e.g., pembrolizumab), which strengthens the body’s defense against cancer cells. In early studies, this combination showed response rates around 45% and a median survival of approximately 18 months in patients for whom previous treatments had failed — results that, while not dramatic, are considered encouraging for this disease.

Scientists now understand that the success of targeted therapy depends on multiple factors. In many patients, cancer cells eventually develop resistance, “learning” to bypass the drug’s effect. In addition, cancers linked to HPV appear to behave differently from those that are not, opening new avenues for more personalized approaches.

Research is also focusing on identifying biomarkers — molecular indicators that can show which patients are most likely to benefit from a particular therapy. If these tools prove reliable, they could lead to more targeted, effective, and safer treatments in the future.

At the same time, newer forms of drugs are being tested, such as bispecific antibodies and antibody–drug conjugates, which aim to target cancer cells with greater precision. All of these efforts are still in early clinical trial stages, aiming to improve efficacy and reduce side effects.

The key message of this research is not that a “new drug that beats cancer” has been found, but that science continues to search, test, and learn. Every small step, every percentage of improvement, every new idea paves the way for future progress.

For people living with cancer — and their families — hope lies not only in major breakthroughs and new treatments but also in the certainty that thousands of researchers around the world are tirelessly working to make each next step a little closer to life. Because in science, as in life, progress is often measured not in leaps but in steady, human steps. At Kapa3, we are committed to sharing this news in a clear and useful way for everyone.

Read the review here

Sources:

Hwang W. et al. “Emerging EGFR-Targeted Therapy in Head and Neck Cancer: A Review.” JAMA Oncology (2025).
World Health Organization – Cancer Research Updates

Text/adaptation: Ifiyenia for Kapa3

New limits on diagnostic tests by EOPYY

What applies to oncology patients

With a new decision by the Ministry of Health (Government Gazette 5325/B/2025), stricter rules are in effect for the repetition of diagnostic tests for EOPYY-insured patients, aiming to reduce costs. However, oncology and hematology patients are exempt in many cases, ensuring continuous and uninterrupted medical monitoring.

What changes

For a series of laboratory and imaging tests (hematology, biochemistry, hormone tests, tumor markers, ultrasounds, CT, MRI, etc.), it is explicitly stated:
“Oncology and hematology patients are exempt”, allowing more frequent repetition when justified by the attending physician.
For tests such as cancer markers, PET/CT scans, and scintigraphy, the exemption is automatic without time restrictions, as these are part of routine disease monitoring.
Oncology patients are also included in the new “Radio-pharmaceutical Reimbursement Procedure”, covering nuclear medicine tests and ensuring full reimbursement.

In summary, for oncology patients, the ability to repeat tests essentially does not change — on the contrary, they are legally protected, as the prescribed exemptions remain.

However, the new framework introduces stricter controls on prescription and reimbursement, which may lead to delays or differences among diagnostic centers and could indirectly affect access and the speed at which tests are carried out.

The full page of the Government Gazette (ΦΕΚ) can be viewed here

Text/adaptation: Ifiyenia Anastasiou for Kapa3

World Food Day: Nourishment as a Pillar of Recovery, Equity & Dignity

Every year on October 16, we pause to remember that food is not a luxury — it is a fundamental human right. As the global theme underscores, “Water is life, water is food. Leave no one behind,” we cannot separate what we eat from how we live, survive, and heal.

The Cancer–Nutrition Connection

For people living with cancer, nutrition can shift from routine to lifeline. The right balance of proteins, micronutrients, hydration, and calories helps sustain strength, improve tolerance of treatments, and support recovery. Yet many cancer patients face serious obstacles: loss of appetite, changes in taste, nausea, fatigue, and swallowing problems. These side effects often lead to undernutrition or weight loss, which in turn can weaken resilience against therapy.

The Shadow of Food Insecurity

The medical challenges compound when food access is uncertain. Studies show that between 17% and 55% of cancer patients worldwide experience food insecurity. Among survivors, those struggling with insecure nutrition have been shown to carry a 28% higher risk of mortality compared to those with stable access. In some research from the U.S., about 6% of older cancer survivors report food insecurity, especially when healthcare costs become “catastrophic” relative to income. These numbers are alarming — they confirm that disease and deprivation often travel together.

The Broader Picture

Food systems globally are strained by climate change, supply chain disruptions, inequalities, and the overuse of ultra-processed foods. In cancer contexts, a 10% increase in ultra-processed food intake has been linked with higher incidence of some cancers (breast, colorectal, head & neck). Ensuring equitable access to fresh, minimally processed foods is critical to prevention and treatment alike.

At Kapa3, we firmly believe that caring for people with cancer goes far beyond medical treatment. Proper nutrition, psychological support, and reliable information are equally important pillars for each person’s wellbeing and dignity.
Raising awareness about nutrition is an essential part of our mission to highlight issues related to quality of life, encourage healthy choices, and remind everyone that even the smallest changes in our daily habits can make a meaningful difference in supporting both patients and their caregivers.

On this World Food Day, let us commit to more than awareness. We must advocate for policies that ensure nutritious food access as part of healthcare, especially for patients facing serious illness. Governments, NGOs, health institutions — all must collaborate to reduce food deserts, subsidize healthy staples, and integrate food security screening into patient care protocols.

In shared meals, there’s more than sustenance: there’s hope, connection, and dignity. Those fighting cancer deserve every bite of comfort, strength, and life — and none should ever be left behind.

Read more about our Holistic Body and Mind Care online Meetings with Kapa3 and the University of the Peloponnese here

New Guide by the Greek Ombudsman on Serving Vulnerable Groups in Public Services

The Greek Ombudsman has released a new, comprehensive Guide addressing the service of vulnerable social groups by public authorities. This important tool for awareness and training aims to improve the quality of service, strengthen equality, and promote respect for the rights of all citizens.

The Guide includes:

The main legal framework and legislative provisions concerning different categories of citizens.
The difficulties and barriers faced by groups such as Roma communities, persons with disabilities, victims of domestic violence, people living with addictions, or citizens with a migrant background.
Practical behavioral guidelines for civil servants to ensure that services are accessible, non-discriminatory, and respectful of each group’s specific needs.
Tools and points of reference (such as helplines, support structures, and competent services) for the immediate guidance of citizens in need.

In this way, the Guide serves as a bridge between citizens and Public Administration, promoting transparency, equal treatment, and social cohesion.

Its significance lies not only in providing up-to-date information and an overview of the relevant legislation, but also in offering clear, practical directions for the daily work of public employees. This ensures that every citizen – regardless of origin, gender, age, or social status – enjoys equal access to quality services.

The Guide is available on the website of the Greek Ombudsman and is recommended for use by all public bodies, welfare organizations, hospitals, municipalities, and citizens’ associations.

KAPA3 supports and highlights such initiatives, which contribute to both citizens’ empowerment and the better preparation of the staff who serve them. Disseminating this Guide is another step toward a society free of exclusion.

Kapa3 participation in the MELODIC consortium meeting in Lisbon

We are delighted to announce that Kapa3 had the opportunity to take part in the recent MELODIC consortium meeting, which was held in Lisbon. Although our participation was online, it was in real time, and our team contributed actively to the discussions, which focused on the development of the training program for healthcare professionals and the design of the intervention study, both aiming to support the mental health of young adults living with cancer.

The MELODIC project, funded by the EU4HEALTH program with a total budget of €1.8 million, addresses a critical yet often overlooked issue: the mental health of young adults aged 18–35 living with cancer.

During the meeting, partners exchanged experiences and findings from European research and interviews with healthcare professionals, families, and young adults with cancer. These insights strengthened collaboration and the formulation of strategies for timely psychosocial support.

Next spring, the project will launch the intervention phase, focusing on social prescribing and the use of green and blue spaces—harnessing the power of nature and community to promote well-being.

Kapa3 continues to work closely with its European partners to ensure a meaningful impact on the lives of young adults facing cancer.

Mount Athos: The Hidden Link Between Spirituality and Health

Mount Athos: The Hidden Link Between Spirituality and Health

In northern Greece, perched on steep cliffs overlooking the Aegean Sea, lies the Holy Monastery of Simonos Petra — one of the twenty monasteries that make up Mount Athos. For more than a thousand years, the monks of the Holy Mountain have lived a simple life of prayer, devoted to their goal of drawing closer to God.

Longevity and Health

Simonos Petra reflects the same spiritual and physical discipline found throughout Mount Athos, where life and health are closely intertwined with faith. Despite a population of around 2,000 monks, there is only one doctor on the Holy Mountain — and rarely needed. Studies have shown that the monks exhibit remarkably low rates of cancer, cardiovascular disease, and Alzheimer’s. In a thirteen-year study of 1,500 monks, not a single case of lung or colon cancer was recorded, while prostate cancer incidence was far below the international average.

Their good health is attributed to a Mediterranean, meat-free diet rich in olive oil and plant proteins, strict adherence to regular meal times, and a labor-intensive, self-sufficient lifestyle: cultivating the land, gathering fruits, maintaining the facilities, and working hard to sustain their daily needs.

The Spiritual Dimension

Beyond diet and lifestyle, the monks themselves believe their health is connected to something deeper: their mystical relationship with God. As Father Maximos says, “You cannot know. It is a mystery that the human mind will never unlock. The only certainty is that spiritual laws are at work. How they operate, only God knows.”

Modern scientific studies suggest that faith and spirituality can strengthen the immune system and reduce the impact of stress on physical health. When religious practice is accompanied by sincere intention and an authentic relationship with the Divine, it can bring deeper peace, resilience, and ultimately, better health.

A Lesson for the Modern World

The example of the monks of Mount Athos shows that health is not only a matter of diet and exercise but also of spiritual balance. In a world full of stress, cultivating inner peace and committing to values such as patience, compassion, and humility may be the most powerful “medicine” for both body and soul.

Source: Article by Elaine Claire Siegfried here

“Kapa3–University Research Lab Collaboration Honored at the Bravo Sustainability Dialogue & Awards 2024”

The University Research Laboratory “Care of Adult Cancer Patients” of the Department of Nursing at the International Hellenic University (IHU), in collaboration with Kapa3, was honored at the Bravo Sustainability Dialogue & Awards 2024 for its contribution to supporting oncology patients and their families.

The award ceremony took place on December 2, 2024, at the Basil & Elise Goulandris Foundation, under the auspices of the Quality Net Foundation. The award was received by Maria Lavdaniti, Director of the Laboratory, together with Evangelia Bista, Development Manager of Kapa3.

The initiative was recognized under the Society pillar, specifically within the thematic category “Quality of Life & Volunteering Actions”, highlighting the importance of academic outreach, as well as the training and hands-on engagement of final-year students and graduates in real-world settings.

Kapa3 played a key role in the development and promotion of the initiative, placing strong emphasis on strengthening social innovation in the health sector. Its core objective was to improve the quality of life of patients and their families through meaningful, community-focused interventions.

The Quality Net Foundation, a non-profit organization promoting sustainable development in Greece since 1997, through the Bravo Sustainability Dialogue & Awards institution, showcases initiatives that support a sustainable future, in collaboration with organizations, businesses, local authorities, and civil society.

The Kapa3 team would like to warmly thank the International Hellenic University for the collaboration and the Quality Net Foundation for recognizing this important initiative, which reaffirms our commitment to developing innovative solutions that promote sustainability and social cohesion.

View photo material from the event

With kind regards,
On behalf of the entire Kapa3 team

Translation: Ifiyenia Anastasiou for Kapa3