Oncology Archives - Page 3 of 3

Gut Microbiota: A Hidden Ally in Cancer Treatment

Our gut is home to trillions of microorganisms, collectively called the gut microbiota, which play a crucial role in digestion, immunity, and overall health. Excitingly, research is revealing that these tiny residents can also influence the effectiveness of cancer treatments—from immunotherapy to chemotherapy and beyond. Understanding this connection opens new possibilities for more personalized and effective cancer care.

Boosting Immunotherapy through Gut Microbes

Innovative therapies like CAR-T cell therapy, immune checkpoint inhibitors (ICIs), oncolytic viruses (OVs), and CpG-oligonucleotide immunotherapy have transformed cancer treatment in recent years. Studies show that the composition of gut microbiota can affect how well patients respond to these therapies.

For instance, certain bacteria—such as Ruminococcus, Faecalibacterium, and Akkermansia—are linked to better CAR-T outcomes, while broad-spectrum antibiotics may reduce therapy effectiveness. Similarly, gut microbes can enhance responses to ICIs by stimulating immune cells that attack tumors. OVs, which work by killing cancer cells and activating the immune system, also benefit from a healthy gut microbiota. Even CpG-based therapies are more effective when gut microbes activate immune pathways.

In short, a balanced gut microbiota can help “turn cold tumors into hot tumors,” making them more responsive to modern immunotherapies.

Gut Microbes and Traditional Treatments

Gut microbiota also affects chemotherapy and radiotherapy. Some microbes can influence drug metabolism, improving efficacy or reducing side effects. For example, bacteria like Enterococcus hirae and Barnesiella intestinihominis enhance the response to cyclophosphamide, a common chemotherapy drug, by activating immune cells.

On the other hand, disruptions in gut microbiota—often caused by antibiotics or radiation—can increase treatment toxicity, leading to issues like intestinal inflammation or mucositis. Promising strategies like fecal microbiota transplantation (FMT) and certain probiotics have shown potential to restore gut balance, reduce side effects, and improve overall outcomes.

Complementary Approaches: TCM and Probiotics

Traditional medicine can also benefit from gut microbes. Traditional Chinese Medicine (TCM) compounds, when processed by gut bacteria, can transform into more potent anti-cancer agents. Certain TCM herbs and formulas can also promote beneficial bacteria while suppressing harmful ones.

Similarly, probiotics, prebiotics, and synbiotics—foods or supplements that nourish or contain helpful bacteria—can support cancer treatment by strengthening gut immunity, reducing inflammation, and enhancing drug effectiveness. For example, in combination with chemotherapy or immunotherapy, synbiotics have been shown to reduce treatment-related side effects while boosting therapeutic benefits.

Emerging Strategies: Engineering the Microbiota

Beyond diet and probiotics, scientists are developing targeted microbiota interventions to fight cancer more precisely. These include:

Engineered microbes, designed to deliver anti-cancer agents directly to tumors.
Phage therapy, using viruses that selectively kill harmful bacteria.
Nanomedicine and OMVs (outer membrane vesicles), which can deliver drugs or immune-stimulating molecules to tumors while sparing healthy microbes.

These cutting-edge approaches are still under study, but they demonstrate the incredible potential of harnessing gut microbes to improve therapy effectiveness and reduce toxicity.

Looking Ahead: Precision Medicine and Microbiota

The future of cancer treatment may increasingly involve personalized microbiota strategies. By analyzing an individual’s gut bacteria and metabolites, clinicians could tailor therapies to maximize efficacy and minimize side effects. Combining microbiota profiling with multi-omics analysis, AI, and big data could allow doctors to predict treatment response and guide interventions in a way that was unimaginable just a decade ago.

While challenges remain—including differences in individual microbiotas, safety considerations, and regulatory hurdles—the potential is enormous. Gut microbiota represents a promising frontier in precision oncology, offering hope for more effective, safer, and individualized cancer care.

Read the full article here

Text/Adaptation: Ifiyenia Anastasiou for Kapa3

Scientific Seminar: Psychosocial Support after Cancer Treatment and Post-Traumatic Growth

The Psychology Laboratory of INEB/CEST (Institute of Applied Biosciences / CERTH), with the support of the Municipality of Thessaloniki, is organizing on Saturday, 1 November 2025 (10:00–15:00), at the “Manolis Anagnostakis” Hall of the Thessaloniki City Hall, the scientific seminar “Psychosocial Support after Cancer Treatment and Post-Traumatic Growth.”

The event, initiated by the Psychology Laboratory as part of the IC-GROWTH research project, focuses on the psychological and social dimensions of life after cancer treatment, highlighting good practices for care, empowerment, and post-traumatic growth.

The program includes expert presentations and an open discussion with the audience, featuring researchers, healthcare professionals, and representatives from patient associations.

Participation is free, but pre-registration is required through the following form:
Registration Form

This seminar offers a valuable opportunity for learning and sharing experiences on psychosocial support and care after cancer treatment.

Kapa3 supports initiatives that strengthen mental health and quality of life for individuals who have experienced cancer.

Date: Saturday, 1 November 2025
Time: 10:00–15:00
Location: “Manolis Anagnostakis” Hall, Thessaloniki City Hall

October 25 – World Breast Cancer Awareness Day

October 25 has been established as World Breast Cancer Awareness Day, a day dedicated to raising awareness, promoting prevention, and supporting people living with this disease. Breast cancer is the most commonly diagnosed cancer among women worldwide, affecting approximately 2.3 million women each year, with 670,000 deaths, while in Greece around 6,000 new cases are diagnosed annually (Source: Globocan 2025). These are not just numbers—they are mothers, sisters, daughters, and friends who deserve hope and dignity.

Survival chances depend on access to early detection and effective treatment: in high-income countries, the five-year survival rate exceeds 90%, while in countries such as India it is 66% and in South Africa only 40%. These inequalities highlight the urgent need for coordinated international action, as incidence and mortality are projected to rise by 40% by 2050 if current trends continue.

Breat scancer does not affect only women—around 1% of diagnoses occur in men, a fact often overlooked. Awareness and education must be inclusive so that no one is left unprotected.

The WHO Global Breast Cancer Initiative, established in 2021, works with countries to reduce breast cancer mortality by strengthening health systems and facilitating access to diagnosis and treatment.

At the same time, psychosocial support for patients and their families is crucial, as a diagnosis affects all aspects of life, from work to daily routines and mental well-being.

International Breast Cancer Awareness Day also calls on communities, health organizations, and authorities to collaborate to improve access to screening and treatment services. Raising awareness about risk factors—such as genetics, age, and lifestyle—and promoting healthy habits helps prevent the disease and reduce health inequalities.

Every individual can contribute: schedule a mammogram, remind friends to do the same, support nonprofit organizations, or participate in awareness activities. Even small gestures, like wearing a pink ribbon or sharing reliable information on social media, make a difference.

At Kapa3, we believe that every woman and person living with cancer deserves support, knowledge, and access to high-quality treatments. Through initiatives in awareness, social support, and empowerment, our goal is to build a society where no life is endangered by lack of information, resources, or care, and wher

e hope and solidarity become powerful allies in the fight against the disease.

Read more on breast cancer:

https://www.kapa3.gr/en/raising-the-standards-europe-s-qa-scheme-for-breast-cancer-services/

Understanding Breast Cancer Risk Factors: What You Can and Can’t Change

October – Breast Cancer Awareness Month

Sources: https://gco.iarc.fr/en

https://www.who.int/initiatives/global-breast-cancer-initiative

https://www.who.int/news-room/fact-sheets/detail/breast-cancer

Text/adaptation: Ifiyenia Anastasiou for Kapa3

KAPA3 at the ESMO Congress: Inspiration and Confirmation That We Are Moving Towards the Future

From October 17 to 20, we attended the ESMO World Congress in Berlin. The event stood out for the active participation of the Greek medical community, which led presentations on clinical data, Real-World Evidence, and up-to-date education in collaboration with the global oncology community. At the same time, Greek teams received awards in various areas (medical, nursing, institutional), inspiring us all with hope for the ongoing developments in oncology care.

Our main goal as KAPA3 was to focus on research addressing the real needs of the population within the framework of the global community. Collaborating with healthcare professionals from around the world allowed us to gather valuable knowledge and experiences. The intensive sessions and discussions broadened our understanding and prompted reflection on the next steps.

Key challenges identified for the patient advocacy community were:

Mandatory multidisciplinary assessment before starting treatment
No patient should begin treatment without undergoing a multidisciplinary assessment, including an oncology nurse, social scientist, and psychologist. This should be considered the minimum standard for all cancer patients.
Certification and quality of multidisciplinary teams
It is our duty to ensure that these teams meet quality standards. Their certification is undoubtedly complex. However, for us at KAPA3, multidisciplinary care is a fundamental criterion for service provision and must be certified. Quality care can significantly improve patient outcomes, as shown by clinical studies and research presented at this year’s congress, with potential improvements in overall survival of up to 10% (Sweden).

We are deeply proud that our work is guided by these standards precisely. In an era of remarkable progress in medicine and new therapies, we continue to strengthen the institution of research and multidisciplinary care, ensuring accessibility and patient-centered approaches aimed at quality of life.

This is the third time we have presented our efforts at an ESMO congress, in collaboration with the International University and the Nursing Department, highlighting our presence at every level. Meanwhile, trainings for other healthcare professionals take place annually within our organization in collaboration with Greek universities.

For Greek patients and their environment, we have not yet reached a point where the quality of care is considered a key objective for the entire oncology community. Our aim is to align with efforts across Europe so that, in the future, multidisciplinary assessments from the first day of diagnosis become standard practice within therapeutic protocols.

At KAPA3, we understand that quality care, inherently multidisciplinary, requires collective effort and collaboration between organizations and professionals to determine the best possible standards.

EGFR: An “Old Target” Gaining New Life in Cancer Research

When science moves forward step by step

Progress in oncology does not always come with dramatic announcements. Often, it is found in studies that show small but meaningful steps. One such case is a recent review in JAMA Oncology exploring new targeted therapies for head and neck cancer — a type of cancer often linked to smoking, alcohol consumption, or HPV infection. At Kapa3, we closely follow these developments to keep patients and their families responsibly informed,

Researchers focused on a protein called EGFR (Epidermal Growth Factor Receptor). Approximately 90% of patients with this type of cancer show overexpression of the protein, making it an attractive target for therapy. In the past, drugs such as cetuximab attempted to “block” EGFR activity, but results were limited. Patients experienced modest improvements without a significant increase in survival.

The new generation of research goes a step further. Combination therapies are being explored, such as targeting EGFR alongside immunotherapy (e.g., pembrolizumab), which strengthens the body’s defense against cancer cells. In early studies, this combination showed response rates around 45% and a median survival of approximately 18 months in patients for whom previous treatments had failed — results that, while not dramatic, are considered encouraging for this disease.

Scientists now understand that the success of targeted therapy depends on multiple factors. In many patients, cancer cells eventually develop resistance, “learning” to bypass the drug’s effect. In addition, cancers linked to HPV appear to behave differently from those that are not, opening new avenues for more personalized approaches.

Research is also focusing on identifying biomarkers — molecular indicators that can show which patients are most likely to benefit from a particular therapy. If these tools prove reliable, they could lead to more targeted, effective, and safer treatments in the future.

At the same time, newer forms of drugs are being tested, such as bispecific antibodies and antibody–drug conjugates, which aim to target cancer cells with greater precision. All of these efforts are still in early clinical trial stages, aiming to improve efficacy and reduce side effects.

The key message of this research is not that a “new drug that beats cancer” has been found, but that science continues to search, test, and learn. Every small step, every percentage of improvement, every new idea paves the way for future progress.

For people living with cancer — and their families — hope lies not only in major breakthroughs and new treatments but also in the certainty that thousands of researchers around the world are tirelessly working to make each next step a little closer to life. Because in science, as in life, progress is often measured not in leaps but in steady, human steps. At Kapa3, we are committed to sharing this news in a clear and useful way for everyone.

Read the review here

Sources:

Hwang W. et al. “Emerging EGFR-Targeted Therapy in Head and Neck Cancer: A Review.” JAMA Oncology (2025).
World Health Organization – Cancer Research Updates

Text/adaptation: Ifiyenia for Kapa3

Continuing the Journey: Holistic Body and Mind Care with Kapa3 and the University of the Peloponnese

After the first round of meetings held in April (see the related article here), focusing on Nutritional Guidance and Experiential Psychological Support, Kapa3 and the University of the Peloponnese continue their collaboration with a new series of experiential workshops dedicated to the holistic care of body and mind.

The meetings are open to people living with cancer, caregivers, and healthcare professionals — to anyone seeking a space for genuine communication, understanding, and empowerment.

In this new cycle, mental health and nutrition are approached as two sides of the same care.

In the mental health sessions, participants learn to recognize and manage challenging emotions such as anxiety or fear, strengthen their resilience, and cultivate a deeper connection with themselves and others.

At the same time, the nutrition sessions explore how balanced and mindful eating can support the body, enhance energy and mood, and become an act of self-care and self-respect. Food is not only a necessity but also a way to show love — to the body, the soul, and to life itself.

The meetings are held online and are based on dialogue, experiential learning, and the sharing of personal experiences. Everyone participates at their own pace, in a warm environment of acceptance and trust.

To express your interest: Registration Form for the Support Group for People with Cancer

Text/adaptation: Ifiyenia for Kapa3

October – Breast Cancer Awareness Month

October is internationally recognized as Breast Cancer Awareness Month, a time dedicated to education, prevention, and support for everyone affected by the disease. Breast cancer remains the most common cancer among women worldwide, yet early diagnosis and advances in treatment have significantly improved both quality and length of life.

The event began in 1985 as a week-long awareness campaign by the American Cancer Society, in partnership with Imperial Chemical Industries, a British company that made tamoxifen. The campaign eventually grew into a month-long event.

The core message of this month is simple but crucial: awareness saves lives. Regular mammograms, self-examinations, and timely medical advice when suspicious signs appear are the most powerful tools for prevention and early detection. International studies show that women who participate in screening programs are more likely to be diagnosed at an early stage, allowing for more effective and less invasive treatment.

However, October is not just about medical tests. It is a month that highlights the importance of psychosocial support and solidarity. Breast cancer affects not only the body but also the mind and spirit. Women – and men – facing this diagnosis need a supportive network of family, friends, healthcare professionals, and organizations to guide, encourage, and stand by them every step of the way.

The Kapa3 Cancer Guidance Center joins the international community in emphasizing the value of accurate information and equitable access to healthcare services. Through informative articles, prevention guides, and psychological support, our goal is to stand by every person in need, providing reliable knowledge and meaningful assistance.

Breast Cancer Awareness Month is more than a campaign: it is a reminder that life can be won when prevention, education, and solidarity become part of our daily practice. October calls on all of us to raise our voices, promote screening, and embrace those fighting their own battles—because no one should face cancer alone.

ESMO Highlights the Importance of Prioritising the Fight Against Cancer in the EU4Health 2026 Work Programme

The European Society for Medical Oncology (ESMO) submitted its response to the public consultation on the 2026 Annual Work Programme of EU4Health, emphasising the urgent need to make cancer a top priority across Europe. With the number of cancer cases projected to rise from over 4.47 million in 2022 to 5.48 million in 2045, ESMO calls for dedicated EU4Health actions to address this growing challenge.

Among the key areas highlighted by ESMO is the importance of improving accessibility to healthcare based on current medical knowledge and international standards, while adequately monitoring the quality of healthcare services to prevent inequalities across the EU. This approach aligns closely with the mission and activities of Kapa3, which aims to ensure equitable access to health support for all, particularly young adults affected by cancer.

Through its initiatives, Kapa3 actively promotes awareness, supports access to quality healthcare, and works to reduce disparities in health services, reflecting the same commitment emphasised by ESMO in its response to EU4Health.

Melodic, A New European Project Supporting the Mental Health of Young Adults with Cancer

At Kapa3, we know that healing goes far beyond the body. A cancer diagnosis in young
adulthood — just as life is beginning to unfold — often leaves deep emotional marks. That’s
why we’re proud to participate in MELODIC, a new European initiative dedicated to
supporting the mental health of young adults (18–30) living with or after cancer.

The project Melodic brings together 13 partners from 6 European countries, including patient organizations, universities, and healthcare experts. Coordinated by Turku University of Applied Sciences (Finland), MELODIC aims to co-design innovative digital tools, peer
support models, and educational workshops that reflect the actual needs and voices of
young people affected by cancer.

Kapa3 joined the project in 2024, and our role is to bring Greek patients’ perspectives to
the table while also ensuring that everything we co-create reaches the people who need it
most — especially here in Greece.

We believe that mental well-being is not a luxury, but a vital part of cancer care. Over the next two years, we’ll be working closely with survivors, caregivers, professionals, and youth groups to build safe spaces for expression, support, and growth.

Want to learn more? Visit our website and check out the new MELODIC subpage to see how
we’re working to make a difference — and how you can get involved.

Together, we can make mental health care more humane, inclusive, and empowering.
Because no one should face cancer — or life after it — alone.

Read more on Melodic project: Melodic Project Mental Health on YAC