Category: Care

EGFR: An “Old Target” Gaining New Life in Cancer Research

When science moves forward step by step

Progress in oncology does not always come with dramatic announcements. Often, it is found in studies that show small but meaningful steps. One such case is a recent review in JAMA Oncology exploring new targeted therapies for head and neck cancer — a type of cancer often linked to smoking, alcohol consumption, or HPV infection. At Kapa3, we closely follow these developments to keep patients and their families responsibly informed,

Researchers focused on a protein called EGFR (Epidermal Growth Factor Receptor). Approximately 90% of patients with this type of cancer show overexpression of the protein, making it an attractive target for therapy. In the past, drugs such as cetuximab attempted to “block” EGFR activity, but results were limited. Patients experienced modest improvements without a significant increase in survival.

The new generation of research goes a step further. Combination therapies are being explored, such as targeting EGFR alongside immunotherapy (e.g., pembrolizumab), which strengthens the body’s defense against cancer cells. In early studies, this combination showed response rates around 45% and a median survival of approximately 18 months in patients for whom previous treatments had failed — results that, while not dramatic, are considered encouraging for this disease.

Scientists now understand that the success of targeted therapy depends on multiple factors. In many patients, cancer cells eventually develop resistance, “learning” to bypass the drug’s effect. In addition, cancers linked to HPV appear to behave differently from those that are not, opening new avenues for more personalized approaches.

Research is also focusing on identifying biomarkers — molecular indicators that can show which patients are most likely to benefit from a particular therapy. If these tools prove reliable, they could lead to more targeted, effective, and safer treatments in the future.

At the same time, newer forms of drugs are being tested, such as bispecific antibodies and antibody–drug conjugates, which aim to target cancer cells with greater precision. All of these efforts are still in early clinical trial stages, aiming to improve efficacy and reduce side effects.

The key message of this research is not that a “new drug that beats cancer” has been found, but that science continues to search, test, and learn. Every small step, every percentage of improvement, every new idea paves the way for future progress.

For people living with cancer — and their families — hope lies not only in major breakthroughs and new treatments but also in the certainty that thousands of researchers around the world are tirelessly working to make each next step a little closer to life. Because in science, as in life, progress is often measured not in leaps but in steady, human steps. At Kapa3, we are committed to sharing this news in a clear and useful way for everyone.

Read the review here

Sources:

Hwang W. et al. “Emerging EGFR-Targeted Therapy in Head and Neck Cancer: A Review.” JAMA Oncology (2025).
World Health Organization – Cancer Research Updates

Text/adaptation: Ifiyenia for Kapa3

Continuing the Journey: Holistic Body and Mind Care with Kapa3 and the University of the Peloponnese

After the first round of meetings held in April (see the related article here), focusing on Nutritional Guidance and Experiential Psychological Support, Kapa3 and the University of the Peloponnese continue their collaboration with a new series of experiential workshops dedicated to the holistic care of body and mind.

The meetings are open to people living with cancer, caregivers, and healthcare professionals — to anyone seeking a space for genuine communication, understanding, and empowerment.

In this new cycle, mental health and nutrition are approached as two sides of the same care.

In the mental health sessions, participants learn to recognize and manage challenging emotions such as anxiety or fear, strengthen their resilience, and cultivate a deeper connection with themselves and others.

At the same time, the nutrition sessions explore how balanced and mindful eating can support the body, enhance energy and mood, and become an act of self-care and self-respect. Food is not only a necessity but also a way to show love — to the body, the soul, and to life itself.

The meetings are held online and are based on dialogue, experiential learning, and the sharing of personal experiences. Everyone participates at their own pace, in a warm environment of acceptance and trust.

To express your interest: Registration Form for the Support Group for People with Cancer

Text/adaptation: Ifiyenia for Kapa3

Understanding Breast Cancer Risk Factors: What You Can and Can’t Change

October is Breast Cancer Awareness Month — a time to raise awareness, share knowledge, and remind ourselves of the importance of early detection and prevention. One of the most common questions people ask is: “What can I do to lower my risk of breast cancer?”

The truth is that while doctors don’t know exactly what causes breast cancer, research has identified certain factors that increase the likelihood of developing the disease. Some of these are beyond our control, while others are linked to lifestyle choices and can be modified. By learning the difference, we empower ourselves to take the best possible care of our health.

Unchangeable Risk Factors

Some risk factors cannot be avoided. These include:

  • Sex: Being female or assigned female at birth is the biggest risk factor.
  • Age: Risk increases with age; two out of three invasive breast cancers occur in women 55 or older.
  • Family History and Genetics: A family history of breast cancer or inherited genetic mutations (such as BRCA1/2) increases risk.
  • Personal History: Women previously diagnosed with breast cancer are more likely to develop it again.
  • Past Radiation: Radiation to the chest or face before age 30 raises risk.
  • Certain Breast Conditions: Some non-cancerous breast changes are linked to higher risk.

Lifestyle-Related Risk Factors

Our daily habits and choices also play a significant role:

  • Weight: Being overweight, especially after menopause, increases risk.
  • Physical Activity: Lack of regular exercise is linked to higher risk.
  • Smoking and Alcohol: Both are associated with increased breast cancer risk.
  • Hormonal Factors: Use of hormone replacement therapy (HRT) or hormonal contraception may raise risk in some women.
  • Reproductive History: Age at first childbirth, number of pregnancies, and breastfeeding history all influence risk.
  • Menstrual History: Early onset of menstruation is associated with slightly higher risk.

Emerging Risk Factors

Research is ongoing, but some additional factors are being studied, such as:

  • Low vitamin D levels.
  • Night-shift work and exposure to bright light at night.
  • Exposure to chemicals (in food, plastics, cosmetics, sunscreens, pesticides, pollution).
  • Frequent consumption of grilled or smoked meats.
  • High levels of air pollution.

Myths and Misconceptions

It’s equally important to clear up what does not increase risk. Research shows no evidence that abortion, antiperspirants, bras, or dairy products cause breast cancer.

We may not be able to control every risk factor, but every small step toward a healthier lifestyle truly makes a difference. Exercise, balanced nutrition, limiting alcohol, and avoiding smoking are not just prevention measures — they’re acts of daily self-care.
At Kapa3, we believe that awareness and support save lives. No one is ever alone on this journey. We promise to continue to speak openly, share knowledge, and stand beside every woman. Because awareness is not about fear; it’s about strength, hope, and small steps toward a healthier tomorrow.

Read More here: https://www.breastcancer.org/risk/risk-factors

Text/Adaptation: Ifiyenia for Kapa3

World Mental Health Day

Every year on 10 October, the world raises its voice for mental health. The World Health Organization reminds us that there is no health without mental health — a truth that is especially important for people living with cancer.

A cancer diagnosis, the treatments, and the uncertainty about the future can create a heavy emotional burden. Many patients experience anxiety, sadness, or feelings of isolation. Studies show that around 30% of people with cancer face psychological challenges such as depression or post-traumatic stress — conditions that affect not only mood but also treatment outcomes and overall well-being.

Psychological distress is not merely a natural reaction to illness; it can influence the immune system, increase chronic inflammation, and reduce the body’s resilience. Behaviourally, it may lead to delays in seeking care, poor adherence to treatment, and social withdrawal. That’s why psychological support is an essential component of cancer care.

A growing body of research shows that interventions like cognitive-behavioral therapy (CBT) and mindfulness-based practices significantly reduce anxiety, depression, fatigue, and stress, while enhancing resilience, post-traumatic growth, and quality of life. Mindfulness-based stress reduction (MBSR), art-based mindfulness, and guided meditation are all proven to help patients regain emotional balance and strength.

At Kapa3 – Cancer Guidance Center, we believe care extends beyond medical treatments. Human connection, understanding, and the sense that “you are not alone” can make all the difference. By providing information, support, and a compassionate presence, we aim to lighten the emotional load for both patients and their families.

World Mental Health Day reminds us that caring for the patient is holistic. Cancer is not only a physical battle; it is an emotional journey — and no journey should be faced alone.

References / Learn more:

World Animal Day: The Healing Presence of Animals

World Animal Day reminds us that we share the planet with all living beings.

Animals are not just companions in our lives; they are an essential part of the balance of nature and our daily world. For many patients, having a pet provides comfort, affection, and a unique bond that eases life’s challenges.

The idea of World Animal Day began in 1925 with Heinrich Zimmermann, who organized the first celebration in Berlin. By 1931, October 4th became officially recognized as a day for all animals. The date is also connected to the feast of Saint Francis of Assisi, the patron saint of animals, symbolizing care and respect for all creatures.

For those fighting cancer, the presence of an animal can be therapeutic. Pet companionship reduces anxiety, brings smiles, and strengthens emotional resilience. Many hospitals abroad use “pet therapy” programs where interaction with animals helps patients feel less alone and more empowered.

At the Kapa3 Cancer Guidance Center, we understand that patient care goes beyond treatment. Mental and emotional well-being is equally important. The power of love—even from a cat or dog—reminds us that no one should walk the path of cancer alone.

World Animal Day calls us to respect all creatures and remember that kindness and affection, wherever we find them, are forms of healing.

You can read more here:

https://nationaltoday.com/world-animal-day/

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