k3-editor, Author at K3 - Page 16 of 23

EGFR: An “Old Target” Gaining New Life in Cancer Research

When science moves forward step by step

Progress in oncology does not always come with dramatic announcements. Often, it is found in studies that show small but meaningful steps. One such case is a recent review in JAMA Oncology exploring new targeted therapies for head and neck cancer — a type of cancer often linked to smoking, alcohol consumption, or HPV infection. At Kapa3, we closely follow these developments to keep patients and their families responsibly informed,

Researchers focused on a protein called EGFR (Epidermal Growth Factor Receptor). Approximately 90% of patients with this type of cancer show overexpression of the protein, making it an attractive target for therapy. In the past, drugs such as cetuximab attempted to “block” EGFR activity, but results were limited. Patients experienced modest improvements without a significant increase in survival.

The new generation of research goes a step further. Combination therapies are being explored, such as targeting EGFR alongside immunotherapy (e.g., pembrolizumab), which strengthens the body’s defense against cancer cells. In early studies, this combination showed response rates around 45% and a median survival of approximately 18 months in patients for whom previous treatments had failed — results that, while not dramatic, are considered encouraging for this disease.

Scientists now understand that the success of targeted therapy depends on multiple factors. In many patients, cancer cells eventually develop resistance, “learning” to bypass the drug’s effect. In addition, cancers linked to HPV appear to behave differently from those that are not, opening new avenues for more personalized approaches.

Research is also focusing on identifying biomarkers — molecular indicators that can show which patients are most likely to benefit from a particular therapy. If these tools prove reliable, they could lead to more targeted, effective, and safer treatments in the future.

At the same time, newer forms of drugs are being tested, such as bispecific antibodies and antibody–drug conjugates, which aim to target cancer cells with greater precision. All of these efforts are still in early clinical trial stages, aiming to improve efficacy and reduce side effects.

The key message of this research is not that a “new drug that beats cancer” has been found, but that science continues to search, test, and learn. Every small step, every percentage of improvement, every new idea paves the way for future progress.

For people living with cancer — and their families — hope lies not only in major breakthroughs and new treatments but also in the certainty that thousands of researchers around the world are tirelessly working to make each next step a little closer to life. Because in science, as in life, progress is often measured not in leaps but in steady, human steps. At Kapa3, we are committed to sharing this news in a clear and useful way for everyone.

Read the review here

Sources:

Hwang W. et al. “Emerging EGFR-Targeted Therapy in Head and Neck Cancer: A Review.” JAMA Oncology (2025).
World Health Organization – Cancer Research Updates

Text/adaptation: Ifiyenia for Kapa3

Continuing the Journey: Holistic Body and Mind Care with Kapa3 and the University of the Peloponnese

After the first round of meetings held in April (see the related article here), focusing on Nutritional Guidance and Experiential Psychological Support, Kapa3 and the University of the Peloponnese continue their collaboration with a new series of experiential workshops dedicated to the holistic care of body and mind.

The meetings are open to people living with cancer, caregivers, and healthcare professionals — to anyone seeking a space for genuine communication, understanding, and empowerment.

In this new cycle, mental health and nutrition are approached as two sides of the same care.

In the mental health sessions, participants learn to recognize and manage challenging emotions such as anxiety or fear, strengthen their resilience, and cultivate a deeper connection with themselves and others.

At the same time, the nutrition sessions explore how balanced and mindful eating can support the body, enhance energy and mood, and become an act of self-care and self-respect. Food is not only a necessity but also a way to show love — to the body, the soul, and to life itself.

The meetings are held online and are based on dialogue, experiential learning, and the sharing of personal experiences. Everyone participates at their own pace, in a warm environment of acceptance and trust.

To express your interest: Registration Form for the Support Group for People with Cancer

Text/adaptation: Ifiyenia for Kapa3

Understanding Breast Cancer Risk Factors: What You Can and Can’t Change

October is Breast Cancer Awareness Month — a time to raise awareness, share knowledge, and remind ourselves of the importance of early detection and prevention. One of the most common questions people ask is: “What can I do to lower my risk of breast cancer?”

The truth is that while doctors don’t know exactly what causes breast cancer, research has identified certain factors that increase the likelihood of developing the disease. Some of these are beyond our control, while others are linked to lifestyle choices and can be modified. By learning the difference, we empower ourselves to take the best possible care of our health.

Unchangeable Risk Factors

Some risk factors cannot be avoided. These include:

Sex: Being female or assigned female at birth is the biggest risk factor.
Age: Risk increases with age; two out of three invasive breast cancers occur in women 55 or older.
Family History and Genetics: A family history of breast cancer or inherited genetic mutations (such as BRCA1/2) increases risk.
Personal History: Women previously diagnosed with breast cancer are more likely to develop it again.
Past Radiation: Radiation to the chest or face before age 30 raises risk.
Certain Breast Conditions: Some non-cancerous breast changes are linked to higher risk.

Lifestyle-Related Risk Factors

Our daily habits and choices also play a significant role:

Weight: Being overweight, especially after menopause, increases risk.
Physical Activity: Lack of regular exercise is linked to higher risk.
Smoking and Alcohol: Both are associated with increased breast cancer risk.
Hormonal Factors: Use of hormone replacement therapy (HRT) or hormonal contraception may raise risk in some women.
Reproductive History: Age at first childbirth, number of pregnancies, and breastfeeding history all influence risk.
Menstrual History: Early onset of menstruation is associated with slightly higher risk.

Emerging Risk Factors

Research is ongoing, but some additional factors are being studied, such as:

Low vitamin D levels.
Night-shift work and exposure to bright light at night.
Exposure to chemicals (in food, plastics, cosmetics, sunscreens, pesticides, pollution).
Frequent consumption of grilled or smoked meats.
High levels of air pollution.

Myths and Misconceptions

It’s equally important to clear up what does not increase risk. Research shows no evidence that abortion, antiperspirants, bras, or dairy products cause breast cancer.

We may not be able to control every risk factor, but every small step toward a healthier lifestyle truly makes a difference. Exercise, balanced nutrition, limiting alcohol, and avoiding smoking are not just prevention measures — they’re acts of daily self-care.
At Kapa3, we believe that awareness and support save lives. No one is ever alone on this journey. We promise to continue to speak openly, share knowledge, and stand beside every woman. Because awareness is not about fear; it’s about strength, hope, and small steps toward a healthier tomorrow.

Text/Adaptation: Ifiyenia for Kapa3

World Osteoporosis Day

Every year on October 20th, the world observes World Osteoporosis Day, a day dedicated to raising awareness about osteoporosis, a condition that weakens bones and increases the risk of fractures. First established by the International Osteoporosis Foundation (IOF) in 1996, the day serves to educate the public on the importance of bone health, early diagnosis, and prevention strategies, highlighting that osteoporosis is not just an age-related issue but a concern affecting millions globally, including younger adults.

Osteoporosis is particularly significant for cancer patients, as both the disease and certain cancer treatments can compromise bone health. Therapies such as hormone deprivation for breast or prostate cancer, long-term steroid use, or chemotherapy may accelerate bone loss, increasing the likelihood of fractures, chronic pain, and reduced mobility. For patients already facing the physical and emotional challenges of cancer, maintaining bone strength becomes essential not only for quality of life but also for their overall recovery and long-term well-being.

In Greece, osteoporosis is a prevalent concern. According to the International Osteoporosis Foundation, approximately 22.3% of women and 6.9% of men aged 50 years or more were estimated to have osteoporosis in 2019. This condition leads to significant health burdens, with 684,000 new fragility fractures reported in 2019 alone. The economic impact is also notable, with the direct cost of incident fractures amounting to €694.7 million in 2019.

For cancer patients, the risk is even higher. Studies indicate that following adjuvant chemotherapy, cancer patients are more likely to develop osteopenia and osteoporosis, affecting up to two-thirds of males and more than half of females. This underscores the importance of proactive bone health management in oncology care.

At Kapa3, we are committed to supporting cancer patients in maintaining optimal bone health. While we do not provide direct medical interventions, we emphasize education, guidance, and psychological support for those navigating health challenges. By promoting awareness of conditions like osteoporosis, especially in the context of cancer care, we aim to empower patients, caregivers, and healthcare providers with knowledge and practical strategies to maintain bone health and prevent complications.

World Osteoporosis Day is a reminder that prevention, timely diagnosis, and lifestyle measures—including nutrition, regular weight-bearing exercise, and appropriate supplementation—play a crucial role in reducing the burden of osteoporosis. Health systems, patient organizations, and communities can work together to ensure that vulnerable populations, including cancer patients, have access to accurate information, screening services, and supportive care.

As we honor this day, Kapa3 encourages everyone to consider bone health as part of comprehensive patient care. By increasing awareness and fostering informed choices, we can help individuals live stronger, safer, and healthier lives, even in the face of serious illness. Osteoporosis may silently weaken bones, but knowledge, prevention, and support can strengthen patients’ resilience and quality of life.

For more information, please refer to the International Osteoporosis Foundation’s report on osteoporosis in Greece: IOF Greece Report.

New limits on diagnostic tests by EOPYY

What applies to oncology patients

With a new decision by the Ministry of Health (Government Gazette 5325/B/2025), stricter rules are in effect for the repetition of diagnostic tests for EOPYY-insured patients, aiming to reduce costs. However, oncology and hematology patients are exempt in many cases, ensuring continuous and uninterrupted medical monitoring.

What changes

For a series of laboratory and imaging tests (hematology, biochemistry, hormone tests, tumor markers, ultrasounds, CT, MRI, etc.), it is explicitly stated:
“Oncology and hematology patients are exempt”, allowing more frequent repetition when justified by the attending physician.
For tests such as cancer markers, PET/CT scans, and scintigraphy, the exemption is automatic without time restrictions, as these are part of routine disease monitoring.
Oncology patients are also included in the new “Radio-pharmaceutical Reimbursement Procedure”, covering nuclear medicine tests and ensuring full reimbursement.

In summary, for oncology patients, the ability to repeat tests essentially does not change — on the contrary, they are legally protected, as the prescribed exemptions remain.

However, the new framework introduces stricter controls on prescription and reimbursement, which may lead to delays or differences among diagnostic centers and could indirectly affect access and the speed at which tests are carried out.

The full page of the Government Gazette (ΦΕΚ) can be viewed here

Text/adaptation: Ifiyenia Anastasiou for Kapa3

Raising the Standards: Europe’s QA Scheme for Breast Cancer Services

The European Quality Assurance (QA) Scheme for Breast Cancer Services, part of the European Commission Initiative on Breast Cancer (ECIBC), is a voluntary certification program covering the full care pathway—from screening to palliative care.

Designed to support quality improvement across Europe, it provides evidence-based guidelines and common quality and safety requirements.

The scheme has been piloted in multiple European countries, confirming its feasibility and usefulness in real healthcare settings. Services meeting the standards can apply for accredited certification, ensuring consistent, high-quality care.

The program is coordinated by the Joint Research Centre (JRC) in collaboration with DG SANTE, under Europe’s Beating Cancer Plan.

To learn more, click here

October 17 – International Day for the Eradication of Poverty

October 17 has been established by the United Nations as the International Day for the Eradication of Poverty, a day dedicated to raising awareness and taking action against a phenomenon that continues to affect millions of people worldwide. The observance began in 1987, when thousands of citizens gathered in Paris to honor the victims of extreme poverty and advocate for a more just and equitable future for all.

Poverty is not only about lack of income—it affects access to education, healthcare, housing, employment, and mental well-being. For people living with serious or chronic illnesses, such as cancer, financial insecurity further complicates daily life, limiting access to treatments, medications, and supportive services.

According to the latest Hellenic Statistical Authority data (Income and Living Conditions Survey 2024), 26.9% of Greece’s population—approximately 2.74 million people—is at risk of poverty or social exclusion, an increase compared to the previous year. Greece ranks second in the EU after Bulgaria, highlighting the difficulty households face in coping with inflation, the energy crisis, and limited social protection.

Globally, according to the United Nations World Social Report 2025, over 690 million people live in extreme poverty (less than $2.15 per day), while 1.1 billion experience multidimensional poverty, lacking access to healthcare, education, and a decent standard of living. Social and economic crises, combined with climate change, disproportionately impact vulnerable households, increasing inequalities and reducing opportunities for stable recovery.

The International Day for the Eradication of Poverty also emphasizes the role of communities and decision-makers in creating inclusive systems. Addressing social determinants of health, ensuring access to essential services, and empowering vulnerable groups are critical to reducing inequalities and improving quality of life. By working together—health professionals, social organizations, and civil society—we can create a world where those facing illness are not further burdened by poverty.

At Kapa3, we firmly believe that access to quality healthcare and decent living conditions are fundamental human rights. Poverty and health are interconnected—the one can easily amplify or worsen the other. Through awareness, empowerment, and social support initiatives, we strive to contribute to a society where no one is deprived of the care they deserve, regardless of income.

Read more: https://www.un.org/en/observances/day-for-eradicating-poverty

https://www.statistics.gr/documents/20181/3d7d2251-2302-9023-5280-a1d962c3a7a5

Kapa3 honored with Gold Award at the Hellenic Responsible Business Awards 2025 NGO of the Year – Health and Social Welfare

A major distinction was awarded to the Cancer Guidance Center – Kapa3, which received the Gold Award in the category “NGO of the Year – Health and Social Welfare” at the Hellenic Responsible Business Awards 2025.

Celebrating its 10th anniversary, the awards recognize organizations and initiatives that promote sustainable entrepreneurship and social impact. The ceremony took place on October 14th at the Anais Club, under the auspices of the Ministry of Development, the Ministry of Environment and Energy, SEV-VIAN, and SETE.

This award highlights Kapa3’s consistent commitment to holistic cancer care, offering free psychosocial guidance, empowerment programs, educational activities, social reintegration initiatives, and innovative digital tools.

Evangelia Bista, President and Founder of Kapa3, stated:

“More than a success, this distinction is a reminder of our values — collaboration, quality, dedication, empathy, and innovation. I am deeply grateful for this exceptional team whose integrity, tireless effort, and shared vision make a difference for our patients. This award belongs to them.”

Since its establishment, Kapa3 has supported more than 10,000 patients and families, while over 1,000 new users visit its website daily for reliable information and guidance. Through scientific evidence, digital innovation, and strong partnerships with public and European stakeholders, Kapa3 promotes a new model of cancer care based on equality, dignity, and inclusion.

As Ms. Bista noted:

“One swallow can make a spring — if you believe in it. And at Kapa3, we’ve been believing it for years, against all odds. We believe.”

“This recognition gives us renewed energy to pursue our mission with dedication, to remain on the frontlines for patients and their families, and to commit every day to improving the support we provide.”

World Food Day: Nourishment as a Pillar of Recovery, Equity & Dignity

Every year on October 16, we pause to remember that food is not a luxury — it is a fundamental human right. As the global theme underscores, “Water is life, water is food. Leave no one behind,” we cannot separate what we eat from how we live, survive, and heal.

The Cancer–Nutrition Connection

For people living with cancer, nutrition can shift from routine to lifeline. The right balance of proteins, micronutrients, hydration, and calories helps sustain strength, improve tolerance of treatments, and support recovery. Yet many cancer patients face serious obstacles: loss of appetite, changes in taste, nausea, fatigue, and swallowing problems. These side effects often lead to undernutrition or weight loss, which in turn can weaken resilience against therapy.

The Shadow of Food Insecurity

The medical challenges compound when food access is uncertain. Studies show that between 17% and 55% of cancer patients worldwide experience food insecurity. Among survivors, those struggling with insecure nutrition have been shown to carry a 28% higher risk of mortality compared to those with stable access. In some research from the U.S., about 6% of older cancer survivors report food insecurity, especially when healthcare costs become “catastrophic” relative to income. These numbers are alarming — they confirm that disease and deprivation often travel together.

The Broader Picture

Food systems globally are strained by climate change, supply chain disruptions, inequalities, and the overuse of ultra-processed foods. In cancer contexts, a 10% increase in ultra-processed food intake has been linked with higher incidence of some cancers (breast, colorectal, head & neck). Ensuring equitable access to fresh, minimally processed foods is critical to prevention and treatment alike.

At Kapa3, we firmly believe that caring for people with cancer goes far beyond medical treatment. Proper nutrition, psychological support, and reliable information are equally important pillars for each person’s wellbeing and dignity.
Raising awareness about nutrition is an essential part of our mission to highlight issues related to quality of life, encourage healthy choices, and remind everyone that even the smallest changes in our daily habits can make a meaningful difference in supporting both patients and their caregivers.

On this World Food Day, let us commit to more than awareness. We must advocate for policies that ensure nutritious food access as part of healthcare, especially for patients facing serious illness. Governments, NGOs, health institutions — all must collaborate to reduce food deserts, subsidize healthy staples, and integrate food security screening into patient care protocols.

In shared meals, there’s more than sustenance: there’s hope, connection, and dignity. Those fighting cancer deserve every bite of comfort, strength, and life — and none should ever be left behind.

Read more about our Holistic Body and Mind Care online Meetings with Kapa3 and the University of the Peloponnese here

October – Breast Cancer Awareness Month

October is internationally recognized as Breast Cancer Awareness Month, a time dedicated to education, prevention, and support for everyone affected by the disease. Breast cancer remains the most common cancer among women worldwide, yet early diagnosis and advances in treatment have significantly improved both quality and length of life.

The event began in 1985 as a week-long awareness campaign by the American Cancer Society, in partnership with Imperial Chemical Industries, a British company that made tamoxifen. The campaign eventually grew into a month-long event.

The core message of this month is simple but crucial: awareness saves lives. Regular mammograms, self-examinations, and timely medical advice when suspicious signs appear are the most powerful tools for prevention and early detection. International studies show that women who participate in screening programs are more likely to be diagnosed at an early stage, allowing for more effective and less invasive treatment.

However, October is not just about medical tests. It is a month that highlights the importance of psychosocial support and solidarity. Breast cancer affects not only the body but also the mind and spirit. Women – and men – facing this diagnosis need a supportive network of family, friends, healthcare professionals, and organizations to guide, encourage, and stand by them every step of the way.

The Kapa3 Cancer Guidance Center joins the international community in emphasizing the value of accurate information and equitable access to healthcare services. Through informative articles, prevention guides, and psychological support, our goal is to stand by every person in need, providing reliable knowledge and meaningful assistance.

Breast Cancer Awareness Month is more than a campaign: it is a reminder that life can be won when prevention, education, and solidarity become part of our daily practice. October calls on all of us to raise our voices, promote screening, and embrace those fighting their own battles—because no one should face cancer alone.